Browsing by Author "Moran, Anthony P."
Now showing items 1-20 of 31
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Altered linkage of hydroxyacyl chains in bacterial lipid a
Moran, Anthony P. (American Society for Biochemistry & Molecular Biology (ASBMB), 2010-07-02) -
An abnormal but functionally active complement component c9 protein found in an irish family with subtotal c9 deficiency
Orren, Ann; O'Hara, Ann M.; Morgan, B. Paul; Moran, Anthony P.; Wurzner, Reinhard (Wiley-Blackwell, 2003-03-01)Two independently segregating C9 genetic defects have previously been reported in two siblings in an Irish family with subtotal C9 deficiency. One defect would lead to an abnormal C9 protein, with replacement of a cysteine ... -
Bacterial infections promote t cell recognition of self-glycolipids
De Libero, Gennaro; Moran, Anthony P.; Gober, Hans-Jürgen; Rossy, Emmanuel; Shamshiev, Abdijapar; Chelnokova, Olga; Mazorra, Zaima; Vendetti, Silvia; Sacchi, Alessandra; Prendergast, Martina M.; Sansano, Sebastiano; Tonevitsky, Alexander; Landmann, Regine; Mori, Lucia (Elsevier BV, 2005-06-01)Recognition of self is essential for repertoire selection, immune regulation, and autoimmunity and may be a consequence of infection. Self-induced recognition may represent the escape mechanism adopted by pathogens but may ... -
Biological activities of lipopolysaccharides are determined by the shape of their lipid a portion
Schromm, Andra B.; Brandenburg, Klaus; Loppnow, Harald; Moran, Anthony P.; Koch, Michel H. J.; Rietschel, Ernst TH.; Seydel, Ulrich (Wiley-Blackwell, 2000-04-01)Lipopolysaccharide (LPS) represents a major virulence factor of Gram-negative bacteria ('endotoxin') that can cause septic shock in mammals including man. The lipid anchor of LPS to the outer membrane, lipid A, has a ... -
Biological characterization ofcampylobacter fetuslipopolysaccharides
Moran, Anthony P.; O'Malley, David T.; Vuopio-Varkila, Jaana; Varkila, Kari; Pyhälä, Liisa; Saxén, Harri; Helander, Ilkka M. (Oxford University Press (OUP), 1996-08-01)Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed ... -
Campylobacter jejuni strain discrimination and temperature-dependent glycome expression profiling by lectin microarray
Kilcoyne, Michelle; Twomey, Marcus E.; Gerlach, Jared Q.; Kane, Marian; Moran, Anthony P.; Joshi, Lokesh (Elsevier, 2014-02-12)Gram-negative Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans worldwide and the most frequently identified infectious trigger in patients developing Guillain-Barré syndrome (GBS). While ... -
Chemical structure of the lipid a component of lipopolysaccharides of the genus pectinatus
Helander, Ilkka M.; Kilpelainen, Ilkka; Vaara, Martti; Moran, Anthony P.; Lindner, Buko; Seydel, Ulrich (Wiley-Blackwell, 1994-08-01)The chemical structure of the lipid A components of smooth-type lipopolysaccharides isolated from the type strains of strictly anaerobic beer-spoilage bacteria Pectinatus cerevisiiphilus and Pectinatus frisingensis were ... -
Comparative chemical and biological characterization of the lipopolysaccharides of gastric and enterohepatic helicobacters
Hynes, Sean O.; Ferris, John A.; Szponar, Bogumila; Wadstrom, Torkel; Fox, James G.; O'Rourke, Jani; Larsson, Lennart; Yaquian, Elisa; Ljungh, Asa; Clyne, Marguerite; Andersen, Leif P.; Moran, Anthony P. (Wiley-Blackwell, 2004-08-01)Background. The lipopolysaccharide of Helicobacter pylori plays an important role in colonization and pathogenicity. The present study sought to compare structural and biological features of lipopolysaccharides from gastric ... -
Different effectiveness of helicobacter pylori lipopolysaccharides with or without lewisxy determinants in stimulating the secretion of proinflammatory cytokines il-8 and tnf-α by peripheral blood mononuclear leukocytes
Rudnicka, Karolina; Grębowska, Aneta; Moran, Anthony P.; Matusiak, Agnieszka; Walencka, Maria; Miszczyk, Eliza; Bąk-Romaniszyn, Leokadia; Czkwianianc, Elżbieta; Płaneta-Małecka, Izabela; Rudnicka, Wiesława; Chmiela, Magdalena (Termedia Sp. z.o.o., 2011-01-01)Introduction: Helicobacter pylori is an aetiological agent of chronic gastritis, gastric and duodenal ulcers, and gastric cancers. It is suggested that H. pylori must have undergone evolutionary changes that enable the ... -
Helicobacter pylori antigens as potential modulators of lymphocytes’ cytotoxic activity
Rudnicka, Karolina; Włodarczyk, Marcin; Moran, Anthony P.; Rechciński, Tomasz; Miszczyk, Eliza; Matusiak, Agnieszka; Szczęsna, Ewelina; Walencka, Maria; Rudnicka, Wiesława; Chmiela, Magdalena (Wiley-Blackwell, 2012-01-01)Helicobacter pylori (H.p) colonizes human gastric mucosa and causes gastric and duodenal ulcer disease or gastric cancer. Various H.p compounds may modulate the host immune response in regards to tolerance of the infection ... -
Helicobacter pyloriheat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (tlr)-2-, tlr-4-, and myeloid differentiation factor 88-independent mechanism
Gobert, Alain P.; Bambou, Jean-Christophe; Werts, Catherine; Balloy, Viviane; Chignard, Michel; Moran, Anthony P.; Ferrero, Richard L. (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-10-22)Helicobacter pylori has been reported to induce interleukin-6 (IL-6) production in monocytes/macrophages and in chronically inflamed gastric tissues. The mechanism by which H. pylori induces IL-6 production in macrophages, ... -
Host recognition of bacterial muramyl dipeptide mediated through nod2
Inohara, Naohiro; Ogura, Yasunori; Fontalba, Ana; Gutierrez, Olga; Pons, Fernando; Crespo, Javier; Fukase, Koichi; Inamura, Seiichi; Kusumoto, Shoichi; Hashimoto, Masahito; Foster, Simon J.; Moran, Anthony P.; Fernandez-Luna, Jose L.; Nuñez, Gabriel (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-01-04)NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical ... -
In vivo expression of the 25-kda laminin-binding protein ofhelicobacter pylori
Moran, Anthony P.; Broaders, Samantha A.; Rapa, Anna; Oderda, Giuseppina (Oxford University Press (OUP), 2005-03-01) -
Influence of activated charcoal, porcine gastric mucin and β-cyclodextrin on the morphology and growth of intestinal and gastric helicobacter spp.
Taneera, Jalal; Hynes, Sean O.; Nilsson, Hans-Olof; Wadström, Torkel; Al-Soud, Waleed abu; Moran, Anthony P. (Microbiology Society, 2002-03-01)Bile-tolerant Helicobacter spp. are emerging human and animal pathogens. However, due to their fastidious nature, which requires nutrient-rich complex media to grow, infection with these bacteria may be underestimated. The ... -
Interaction ofhelicobacter pyloriwith c-type lectin dendritic cell-specific icam grabbing nonintegrin
Miszczyk, Eliza; Rudnicka, Karolina; Moran, Anthony P.; Fol, Marek; Kowalewicz-Kulbat, Magdalena; Druszczyńska, Magdalena; Matusiak, Agnieszka; Walencka, Maria; Rudnicka, Wiesława; Chmiela, Magdalena (Hindawi Limited, 2012-01-01)In this study we asked whether Helicobacter pylori whole cells and lipopolysaccharide (LPS) utilize sugar moieties of Lewis (Le) antigenic determinants to interact with DC-SIGN (dendritic cell specific ICAM grabbing ... -
Lewis x structures in the o antigen side-chain promote adhesion of helicobacter pylori to the gastric epithelium
Edwards, Nicola J.; Monteiro, Mario A.; Faller, Gerhard; Walsh, Evelyn J.; Moran, Anthony P.; Roberts, Ian S.; High, Nicola J. (Wiley-Blackwell, 2002-01-18)Helicobacter pylori NCTC11637 expresses a lipopolysaccharide (LPS) that comprises an O antigen side-chain with structural homology to the human blood group antigen Lewis X (Le(x)). The role of this molecule in adhesion of ... -
Lipopolysaccharide diversity evolving in helicobacter pylori communities through genetic modifications in fucosyltransferases
Nilsson, Christina; Skoglund, Anna; Moran, Anthony P.; Annuk, Heidi; Engstrand, Lars; Normark, Staffan (Public Library of Science (PLoS), 2008-11-26)Helicobacter pylori persistently colonizes the gastric mucosa of half the human population. It is one of the most genetically diverse bacterial organisms and subvariants are continuously emerging within an H. pylori ... -
Lipopolysaccharide structures of helicobacter pylori genomic strains 26695 and j99, mouse model h. pylori sydney strain, h. pylori p466 carrying sialyl lewis x, and h. pylori ua915 expressing lewis b
Monteiro, Mario A.; Appelmelk, Ben J.; Rasko, David A.; Moran, Anthony P.; Hynes, Sean O.; MacLean, Leann L.; Chan, Ken H.; Michael, Frank St; Logan, Susan M.; O'Rourke, Jani; Lee, Adrian; Taylor, Diane E.; Perry, Malcolm B. (Wiley-Blackwell, 2000-01-01)This study describes the molecular makeup of the cell-wall lipopolysaccharides (LPSs) (O-chain polysaccharide-->core oligosaccharide-->lipid A) from five Helicobacter pylori strains: H. pylori 26695 and J99, the ... -
Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease
Moran, Anthony P.; Prendergast, Martina M.; Appelmelk, Ben J. (Oxford University Press (OUP), 1996-12-01)The core oligosaccharides of low-molecular-weight lipopolysaccharide (LPS), also termed lipooligosaccharide (LOS), of pathogenic Neisseria spp. mimic the carbohydrate moieties of glycosphingolipids present on human cells. ... -
Molecular origin of two polysaccharides ofcampylobacter jejuni81116
Kilcoyne, Michelle; Moran, Anthony P.; Shashkov, Alexander S.; Senchenkova, Sof'ya N.; Ferris, John A.; Corcoran, Adrian T.; Savage, Angela V. (Oxford University Press (OUP), 2006-10-01)The nature of the polysaccharide molecules of the human enteric pathogen Campylobacter jejuni has been the subject of debate. Previously, C. jejuni 81116 was shown to contain two different polysaccharides, one acidic ...