Browsing by Subject "Medicine, Nursing and Health Sciences"
Now showing items 1-20 of 69
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Access to maternal healthcare in post-conflict South Sudan. Is the health system designed for the context?
(2015-05-09)Background: The importance of understanding the cultural, social, economic, political and historical contexts when working in post conflict fragile states is well documented. Many health and development projects in post ... -
Adaptive clinical trials of sodium lowering in chronic kidney disease and dialysis: Analytic and methodologic challenges
(NUI Galway, 2022-04-24)The incidence and prevalence of kidney failure requiring dialysis is rising. Patients receiving dialysis are at increased cardiovascular risk, compared to the general population. Hypertension due to sodium and volume excess ... -
Advanced therapies in pancreatic islet transplantation for type 1 diabetes mellitus
(NUI Galway, 2023-03-14)Type 1 diabetes mellitus is an autoimmune condition whereby β-cells are destroyed by the immune system causing the lack/absence of insulin production and resultant hyperglycaemia. Pancreatic islet transplantation is ... -
Advances in the management and treatment algorithms for anterior shoulder instability
(NUI Galway, 2022-04-28)Anterior shoulder instability is a common clinical problem, with a reported incidence ranging from 8 to 25 per 100,000 person years in the general population, with higher rates seen 1-3 in athletic populations. However, ... -
Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
(2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Application of CRISPR/Cas9 gene editing to target Neuronal Interleukin-16 a novel protein involved in osteoarthritis progression
(NUI Galway, 2022-09-07)Osteoarthritis (OA) is a debilitating joint disease affecting an increasing proportion of the elderly population worldwide annually. Current treatments for the disease are symptomatic with management of pain and side effects ... -
Assessment of measuring and monitoring safety in healthcare in Ireland and Saudi Arabia
(NUI Galway, 2024-03-04)In the past two decades, governments worldwide have prioritised the improvement of health care quality and safety as a primary policy goal. However, progress towards achieving this goal has been limited. The provision ... -
Characterisation and analysis of Memory T-cells in COVID-19 patient sample
(NUI Galway, 2023-08-08)Background: Immunological memory is the key to long-term protection against disease. It is the hallmark of adaptive immunity which facilitates an accelerated and enhanced immune response against a pathogen encountered ... -
COHESION core outcomes in neonatal encephalopathy
(NUI Galway, 2022-12-05)Neonatal encephalopathy is a complex neurological syndrome in newborn infants characterised by depression in tone and consciousness, impaired reflexes, and often seizures. The main subtype of neonatal encephalopathy is ... -
A compendium of the steps required to complete 13 essential procedural skills
(University of Galway, 2022-09)Entrustable Professional Activities (EPAs) are units of professional practice that capture essential competencies in which trainees must become proficient before undertaking them independently. EPAs provide supervisors ... -
The context and circumstances of early sexual initiation among adolescents in Ireland: A mixed methods investigation
(NUI Galway, 2020-08-25)Adolescents who initiate sexual intercourse at early ages may be at a heightened risk of negative sexual health outcomes at the time of first sex and later in life. In the case of Ireland, there is inadequate knowledge ... -
Current and potential diagnostic modalities in the detection and management of breast cancer
(NUI Galway, 2021-07-06)Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ... -
Development of 3D breast cancer model to study extracellular vesicle crosstalk
(NUI Galway, 2024-01-31)3D model systems are crucial in establishing novel therapeutics and understanding cell interactions in the tumor microenvironment. Extracellular vesicles (EVs) are promising carriers of therapeutic cargo for tumor-targeted ... -
Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell applications
(NUI Galway, 2021-08-04)Chemical compounds synthetized by living organisms have historically contributed to improved human health. Ancient populations made use of local natural products through herbal medicine, which today are to be found as ... -
Development of a mesenchymal stromal cell / collagen scaffold product for treatment of diabetic wounds
(NUI Galway, 2022-08-23)Foot ulceration is a major complication of diabetes mellitus, which results in significant human suffering and a major burden on healthcare systems. Mesenchymal stromal cells (MSCs) emerged as a promising therapeutic ... -
Developments in health literacy over time: A longitudinal qualitative research study
(NUI Galway, 2019-12-12)Introduction Conceptualising health literacy as a relational concept, which involves how individuals interact with complex health and social systems, requires a greater understanding of the context of people’s health ... -
Dynamics of GFP tagged chromatin factors RSF1, CENPS and CENPX at microirradiation induced DNA damage sites
(NUI Galway, 2022-02-22)Chromatin has a major influence on the DNA damage response (DDR). Several chromatin-related factors contribute to the DDR including the CENPS and CENPX histone fold proteins, also known as MHF1 and MHF2, and the chromatin ... -
Effect of glycaemic excursions on QT interval in diabetes patients
(NUI Galway, 2023-09-19)Glucose excursions in Diabetes Mellitus patients are associated with increased risk of cardiac morbidity and mortality (Kaul, Tarr, Ahmad, Kohner, & Chibber, 2013). With the evidence from several clinical trials, it ... -
The effectiveness of pilates in preventing falls in healthy older adults
(NUI Galway, 2021-08)Falls are a major cause of morbidity and mortality in older adults and evidence suggests that fall rates are rapidly increasing likely due to an aging population, which is placing a significant financial burden on health ... -
Enhancing the immunomodulatory efficacy of allogeneic mesenchymal stromal cells through pro-inflammatory cytokine licensing
(NUI Galway, 2024-04-17)The therapeutic efficacy and immunomodulatory potential of mesenchymal stromal cells (MSCs) is well established. MSCs have been employed as cellular therapies to treat various inflammatory-based conditions. MSC potency can ...