Browsing by Author "McMahon, Siobhan"
Now showing items 1-12 of 12
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Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan (Elsevier, 2018-09-26)Background: The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an altemative model extremely attractive. The use ofex vivo slice cultures is an ... -
Assembly of protein-based hollow spheres encapsulating a therapeutic factor
Kraskiewicz, Honorata; Breen, Bridget; Sargeant, Timothy; McMahon, Siobhan; Pandit, Abhay (American Chemical Society (ACS), 2013-09-18)Neurotrophins, as important regulators of neural development, function, and survival, have a therapeutic potential to repair damaged neurons. However, a controlled delivery of therapeutic molecules to injured tissue remains ... -
Assembly of protein-based hollow spheres encapsulating a therapeutic factor
Kraskiewicz, Honorata; Breen, Bridget; Sargeant, Timothy; McMahon, Siobhan; Pandit, Abhay (American Chemical Society, 2013-06-13)Neurotrophins, as important regulators of neural development, function and survival, have a therapeutic potential to repair damaged neurons. However, a controlled delivery of therapeutic molecules to injured tissue remains ... -
Axonal Regeneration Supported by Oligo[poly(ethylene glycol)fumarate] Cell-Loaded Hydrogel Scaffolds in the Transected Rat Spinal Cord
Madigan, Nicolas Niall (2012-04-16)Spinal cord injury results in complete tissue destruction and irreversible loss of neurologic function below the level of the lesion in 40% of patients in Ireland. Tissue engineering using polymer scaffolds offers potential ... -
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
Ab Patar, Mohd Nor Azim (NUI Galway, 2018-04-13)There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ... -
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
Ronan, Rachel (NUI Galway, 2020-02-04)Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ... -
Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein
Abu-Rub, Mohammad T.; Billiar, Kristen L.; van Es, Maarten H.; Knight, Andrew; Rodriguez, Brian J.; Zeugolis, Dimitrios I.; McMahon, Siobhan; Windebank, Anthony J.; Pandit, Abhay (Royal Society of Chemistry (RSC), 2011-01-01)The development of nerve guidance conduits is constantly evolving as the need arises for therapies for spinal cord injury. In addition to providing a path for regrowing axons to reconnect with their appropriate targets, ... -
Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein
Abu-Rub, Mohammad T.; Zeugolis, Dimitrios I.; McMahon, Siobhan; Pandit, Abhay (Royal Society of Chemistry, 2011-01-11)The development of nerve guidance conduits is constantly evolving as the need arises for therapies for spinal cord injury. In addition to providing a path for regrowing axons to reconnect with their appropriate targets, ... -
Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord Without Differentiating into Neural Cells
Rooney, Gemma E.; McMahon, Siobhan; Ritter, Thomas; Garcia, Yolanda; Moran, Cathal; Madigan, Nicholas N. (Mary Ann Liebert, 2009-10)The aim of this study was to assess the feasibility of transplanting mesenchymal stem cells (MSCs), genetically modified to express glial-derived neurotrophic factor (GDNF), to the contused rat spinal cord, and to subsequently ... -
Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes
Abu-Rub, Mohammad T.; Newland, Ben; Naughton, Michelle; Wang, Wenxin; McMahon, Siobhan; Pandit, Abhay (Elsevier, 2016-10-13)Reactive astrocytosis and the subsequent glial scar is ubiquitous to injuries of the central nervous system, especially spinal cord injury (SCI) and primarily serves to protect against further damage, but is also a prominent ... -
Spinal cord injury in vitro: Modelling axon growth inhibition
Abu-Rub, Mohammad; McMahon, Siobhan; Zeugolis, Dimitrios I.; Pandit, Abhay (Elsevier, 2010-06)Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. ... -
Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro
McMahon, Siobhan; Nikolskaya, Natalia; Ní Choileain, Siobhan; Hennessy, Niamh; O'Brien, Timothy; Rochev, Yury (Wiley, 2011-11-01)Background The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried ...