Browsing by Author "McMahon, Jill"
Now showing items 1-9 of 9
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874. prolonged adenovirus and adeno-associated virus-mediated gene delivery to rabbit iliac arteries using gene-eluting stents: a direct comparison
Sharif, Faisal; Hynes, Sean; McMahon, Jill; Crowley, James; Daly, Kieran (Elsevier BV, 2006-01-01) -
Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination
Ní Fhlathartaigh, Mary; McMahon, Jill; Reynolds, Richard; Connolly, David; Higgins, Eibhlín; Counihan, Timothy; FitzGerald, Una (Springer Nature, 2013-01-01)Background: Calreticulin (CRT) is a chaperone protein, which aids correct folding of glycosylated proteins in the endoplasmic reticulum (ER). Under conditions of ER stress, CRT is upregulated and may be displayed on the ... -
Endoplasmic Reticulum Stress as a Component of Demyelination in Animal Models of Multiple Sclerosis
Ní Fhlathartaigh, Mary (2012-12-19)Endoplasmic reticulum (ER) stress is a homeostatic signalling pathway, linked to many neurological diseases including multiple sclerosis (MS), which can lead to cell death when prolonged. Increasing evidence suggests that ... -
Ex vivo investigation of iron handling in the brain
Healy, Sinead (2016-11-04)Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ... -
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
Sharif, Faisal; Hynes, Sean O; Cooney, Ronan; Howard, Linda; McMahon, Jill; Daly, Kieran; Crowley, James; Barry, Frank; O'Brien, Timothy (Elsevier BV, 2008-10-01)Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ... -
Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
Mháille, Aoife Ní; McQuaid, Stephen; Windebank, Anthony; Cunnea, Paula; McMahon, Jill; Samali, Afshin; FitzGerald, Una (Oxford University Press (OUP), 2008-03-01)Activation of endoplasmic reticulum (ER) stress-related cell signals has been reported in several neurologic disorders and may contribute to neurodegeneration. Endoplasmic reticulum stress is also linked to ischemic injury. ... -
Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia
McGinley, Lisa; McMahon, Jill; Strappe, Padraig; Barry, Frank; Murphy, Mary; O'Toole, Daniel; O'Brien, Timothy (Springer Nature, 2011-01-01)Introduction: A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if ... -
Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression
McGinley, Lisa M.; McMahon, Jill; Stocca, Alessia; Duffy, Aoife; Flynn, Aidan; O'Toole, Daniel; O'Brien, Timothy (Mary Ann Liebert Inc, 2013-10-01)Mesenchymal stem cell (MSC) therapy offers the potential to promote recovery after myocardial infarction (MI). However, therapeutic efficacy may be limited by poor survival and retention of transplanted cells. A combination ... -
The effects of blood–brain barrier disruption on glial cell function in multiple sclerosis: figure 1
McQuaid, Stephen; Cunnea, Paula; McMahon, Jill; Fitzgerald, Una (Portland Press Ltd., 2009-02-01)Dysfunction of the BBB (blood-brain barrier) is a major hallmark of MS (multiple sclerosis). Studies in our laboratories over the last decade have shown that increased 131313 permeability is associated with decreased ...