Browsing by Author "McHugh, Peter E."
Now showing items 1-20 of 24
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3D Printing of Microspheres for Tissue Engineering Scaffolds
Lohfeld, Stefan; Salash, J. R.; McHugh, Peter E.; Detamore, M.S. (Mary Ann Liebert, 2015-09)Microspheres have tremendous potential as a scaffold material for tissue engineering applications due to their capability of encapsulation and controlled release of factors that assist tissue regeneration in the desired ... -
Analysis of the mechanical performance of a biodegradable magnesium stent in a remodelling artery
Boland, Enda L. (NUI Galway, 2018-09-28)Coronary stents made from degradable biomaterials such as magnesium alloy are an emerging technology in the treatment of coronary artery disease. Biodegradable stents provide mechanical support to the artery during the ... -
Anterior cruciate ligament graft tensioning. Is the maximal sustained one-handed pull technique reproducible?
O'Neill, Barry; Byrne, Fergus J.; Hirpara, Kieran M.; Brennan, William F.; McHugh, Peter E. (2011)Background Tensioning of anterior cruciate ligament (ACL) reconstruction grafts affects the clinical outcome of the procedure. As yet, no consensus has been reached regarding the optimum initial tension in an ACL graft. ... -
Comparing coronary stent material performance on a common geometric platform through simulated bench testing
Grogan, James A.; Leen, Sean B.; McHugh, Peter E. (Elsevier ScienceDirect, 2012-03-02)Absorbable metallic stents (AMSs) are a newly emerging cardiovascular technology which has the potential to eliminate long-term patient health risks associated with conventional permanent stents. AMSs developed to date ... -
Computational modelling of the degradation of poly-L-lactide for a bioresorbable polymeric stent
Shine, Rosa Connor (NUI Galway, 2020-05-08)The interest in biodegradable polymers for the design of bioresorbable stents, temporary vascular scaffolds designed to restore patency to obstructed vessels, has witnessed a dramatic growth over the last ten to fifteen ... -
Dependence of mechanical properties of polyamide components on build parameters in the SLS process
Lohfeld, Stefan; McHugh, Peter E.; Caulfield, Brian (Elsevier, 2007)Customised properties of parts manufactured using the selective laser sintering process are achievable by variation of build parameters. The energy density, controlled by laser power, distance between scan lines and speed ... -
Design and manufacturing of customised maxillofacial prostheses.
Serban, D.; Boyle, D.; Lohfeld, Stefan; McHugh, Peter E.; Peckitt, N. (Elsevier, 2003-04-28)Customised implants created by Computer-Assisted Surgery (CAS) techniques and used in maxillofacial reconstruction indicate improved outcomes over conventional techniques. ‘‘Non-functional’’ multistaged procedures are ... -
Development of a gene-eluting stent for the treatment of in-stent restenosis
Ganly, Sandra Maria (2016-05-12)In-stent restenosis (ISR) results from stent-induced arterial injury, characterized by a complex cascade of cellular and biochemical events. The removal of endothelium during an angioplasty procedure causes the underlying ... -
Engineering assisted surgery: A route for digital design and manufacturing of customized maxillofacial implants
Serban, D.; Boyle, D.; O'Donnell, G.; Lohfeld, Stefan; McHugh, Peter E.; Peckitt, Ninian (Elsevier, 2007)Rapid prototyping (RP) and more recently rapid manufacturing (RM) as a part of Engineering Assisted Surgery enables manufacturing of customised implants and prostheses prior to surgical procedures. Beginning with CT ... -
An enhanced phenomenological model to predict surface-based localised corrosion of magnesium alloys for medical use
Quinn, Conall; Van Gaalen, Kerstin; McHugh, Peter E.; Kopp, Alexander; Vaughan, Ted J. (Elsevier, 2023-01-05)This study developed an enhanced phenomenological model for the predictions of surface-based localised corrosion of magnesium alloys for use in medical applications. The modelling framework extended previous surface-based ... -
Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered PCL/b-TCP materials
Doyle, Heather; Lohfeld, Stefan; McHugh, Peter E. (Elsevier, 2015-06-06)Orthopaedic scaffold materials were fabricated from polycaprolactone (PCL) and composite PCL β-tricalcium phosphate (PCL/β-TCP) powders using selective laser sintering (SLS). Incorporating β-TCP particles is ... -
Evaluation of a multiscale modelling methodology to predict the mechanical properties of PCL/β-TCP sintered scaffold materials
Doyle, Heather; Lohfeld, Stefan; McDonnell, Pat; McHugh, Peter E. (Springer Verlag, 2014-12-02)A multiscale modelling methodology to predict the macroscale stiffness of selective laser sintered polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) materials is evaluated. The relationship between a micromechanics-evaluated ... -
Experimental mechanical testing of Poly (l-Lactide) (PLLA) to facilitate pre-degradation characteristics for application in cardiovascular stenting
Bobel, Anna C.; Lohfeld, Stefan; Shirazi, Reyhaneh Neghabat; McHugh, Peter E. (Elsevier, 2016-07-19)Next-generation stents made from Biodegradable Polymers (BPs) aim to address the long-term risks (i.e. late restenosis and in-stent thrombosis) associated with both Bare Metal Stents and Drug Eluting Stents, whilst aiming ... -
Finite element predictions compared to experimental results for the effective modulus of bone tissue engineering scaffolds fabricated by selective laser sintering
Lohfeld, Stefan; McHugh, Peter E.; Cahill, Senan (Springer Verlag, 2009)A current challenge in bone tissue engineering is to create scaffolds with suitable mechanical properties, high porosity, full interconnectivity and suitable pore size. In this paper, polyamide and polycaprolactone scaffolds ... -
Gefitinib/gefitinib microspheres loaded polyurethane constructs as drug-eluting stent coating
Chen, Weiluan; Clauser, Johanna; Thiebes, Anja Lena; McGrath, Donnacha J.; Kelly, Nicola; van Steenbergen, Mies J.; Jockenhoevel, Stefan; Steinseifer, Ulrich; McHugh, Peter E.; Hennink, Wim E.; Kok, Robbert J. (Elsevier BV, 2017-05-01) -
Improving the finite element model accuracy of tissue engineered scaffolds produced by selective laser sintering
Lohfeld, Stefan; Cahill, Senan; Doyle, Heather; McHugh, Peter E. (Springer Verlag, 2015-01-13)In bone tissue engineering, both geometrical and mechanical properties of a scaffold play a major part in the success of the treatment. The mechanical stresses and strains that act on cells on a scaffold in a physiological ... -
Investigation of the mechanical interaction of the trabecular core with an external shell using rapid prototype and finite element models
Mc Donnell, Patricia E.; Harrison, Noel M.; Lohfeld, Stefan; Kennedy, Oran; Zhang, Y.; McHugh, Peter E. (Elsevier, 2009-04-05)The mechanical properties of vertebral bone have been widely studied with the ultimate goal of improving fracture risk prediction. However, the mechanical interaction between the cortical shell and the trabecular core is ... -
Laser sintering for the fabrication of tissue engineering scaffolds
Lohfeld, Stefan; McHugh, Peter E. (Springer Science+Business Media, 2012)Laser sintering (LS) utilises a laser to sinter powder particles. A volumetric model is sliced and processedcross section by cross section to create a physical part. In theory, all powdered materials are suitable forsintering; ... -
Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
Birmingham, Evelyn; Kreipke, T. C.; Dolan, E.B.; Coughlin, T.R.; Owens, Peter; McNamara, Laoise M.; Niebur, G.L.; McHugh, Peter E. (Springer Verlag, 2014-10-04)Abstract Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which ... -
Micro-scale testing and micromechanical modelling for high cycle fatigue for CoCr stent material
Sweeney, Caoimhe A.; O'Brien, Barry; McHugh, Peter E. (Elsevier ScienceDirect, 2015-02-20)This paper presents a framework of experimental testing and crystal plasticity micromechanics for high cycle fatigue (HCF) of micro-scale L605 CoCr stent material. Micro-scale specimens, representative of stent struts, are ...