Browsing by Author "McGarry, Patrick"
Now showing items 1-20 of 21
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Analysis and Implementation of Mixed-Mode Cohesive Zone Formulations for Cardiovascular Biomechanics Applications
Ó Máirtín, Éamonn (2013-02-18)A comprehensive theoretical analysis of potential-based and non-potential-based cohesive zone models (CZMs) under mixed-mode conditions is presented. Using the well established Xu-Needleman (XN) CZM, it is demonstrated ... -
Carbon fibre reinforced PEEK laminated as a material for orthopaedic devices: An experimental and computational investigation
Gallagher, Elizabeth Anne (NUI Galway, 2018-11-27)The overall objective of this thesis is to investigate carbon fibre reinforced poly-ether-ether-ketone (PEEK) laminates as a material for fracture fixation devices through a combination of experimental testing and computational ... -
A computational and experimental investigation of the dissection of arterial tissue
FitzGibbon, Brian (NUI Galway, 2020-11-19)The overall objective of this thesis is to provide a new understanding of the mechanisms underlying arterial fracture, and to extend this understanding to the initiation and propagation of aortic dissection using a combination ... -
A computational and experimental investigation of the in-vivo biomechanics of the human aorta
Concannon, Jamie (NUI Galway, 2020-07-06)The overall objective of this thesis is to provide a new understanding of the degree of biomechanical heterogeneity that exists along the human aorta, against the backdrop of clinical literature reporting that patient ... -
Cortical Bone Fracture and Orthopaedic Fixation Devices: An Experimental and Computational Investigation
Feerick, Emer M (2012-09-28)An experimental and computational investigation of cortical bone failure mechanisms has been conducted in this thesis. Firstly, a computational comparison of four methods of proximal humeral fracture fixation was conducted. ... -
The Development of a Computational Test-Bed to Assess Coronary Stent Implantation
Conway, Claire (2013-03-15)The implantation behaviour of coronary stents is of great interest to clinicians and engineers alike as in-stent restenosis (ISR) remains a critical issue with the community. ISR is hypothesized to occur for ... -
Effect of calcium triphosphate cement on proximal humeral fracture osteosynthesis: a finite element analysis
Kennedy, Jim; Feerick, Emer; McGarry, Patrick; FitzPatrick, David; Mullett, Hannan (SAGE Publications, 2013-08-01)Purpose. To measure the effect of void-filling calcium triphosphate cement on the loads at the implant-bone interface of a proximal humeral fracture osteosynthesis using a finite element analysis. Methods. Finite element ... -
Experimental and computational investigation of adhesion junction mechanosensation
Griffin, Fiona (2017-02-28)Bone is an adaptive tissue that remodels in response to the mechanical loads placed upon it during normal daily activity. This remodelling process is vital to maintaining the mechanical integrity, mass and structure of ... -
Experimental and computational investigation of atherosclerotic plaque biomechanics
O'Reilly, Brían L. (NUI Galway, 2019-11-22)The overall objective of this thesis is to provide new insights into the composition and biomechanical behaviour of atherosclerotic plaque. Experimental and computational analysis techniques are developed to investigate ... -
Experimental and computational investigation of the active force generation of cells subjected to static and dynamic loading
Reynolds, Noel (2016-05-13)The development of a mechanistic understanding of the processes by which cells sense and actively respond to the mechanical environment would represent a significant advance in the fields of biomechanics and tissue ... -
An Experimental and Computational Investigation of the Inelastic Behaviour of Trabecular Bone
Kelly, Nicola (2012-09-28)Achieving sufficient initial implant stability is of paramount importance for orthopaedic device longevity. In order to improve the design of orthopaedic devices it is essential to gain a better understanding of the ... -
Experimental Investigation of the Response of Osteoblasts to Static and Dynamic Loading using a Modified Atomic Force Microscope
Weafer, Paul (2013-02-07)Cells and tissues continuously experience mechanical loading during daily activity. However, the mechanisms by which cells respond to mechanical stimuli are poorly understood. The focus of this thesis is to develop atomic ... -
Non-linear anisotropic mechanical behaviour of hard and soft tissues
Nolan, David Robert (2015-09-30)The overall objective of this thesis is to develop accurate and rigorous constitutive formulations for the non-linear anisotropic behaviour of soft tissue (arterial) and hard tissues (trabecular bone) at large strains. The ... -
On anisotropic elasticity and questions concerning its Finite Element implementation
Vergori, Luigi; Destrade, Michel; McGarry, Patrick; Ogden, Ray W. (Springer, 2013-05-21)We give conditions on the strain-energy function of nonlinear anisotropic hyperelastic materials that ensure compatibility with the classical linear theories of anisotropic elasticity. We uncover the limitations associated ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part I: Theoretical Analysis
McGarry, Patrick; Ó Máirtín, Éamonn (2013)This paper presents a thorough analysis of potential-based and non-potential-based cohesive zone models (CZMs) under conditions of mixed-mode separation and mixed-mode over-closure. Problems are identified with the well ... -
Potential-based and non-potential-based cohesive zone formulations under mixed-mode separation and over-closure. Part II: Finite element applications
Ó Máirtín, Éamonn; McGarry, Patrick (2013)This paper, the second of two parts, presents three novel finite element case studies to demonstrate the importance of normal-tangential coupling in cohesive zone models (CZMs) for the prediction of mixed-mode interface ... -
The Response of Cells to the Mechanical Environment: A Numerical Investigation of the Actin Cytoskeleton and Cell Adhesion
Ronan, William (2012-10-21)Numerous in-vitro studies have established that cells possess the ability to sense and react to their physical environment. However, the mechanisms underlying such mechanotransduction are poorly understood. Previous cell ... -
Simulation of the Mechanical Response of Cells on Micropost Substrates
Ronan, William; McGarry, Patrick (American Society of Mechanical Engineers, 2013-09-20)Experimental studies where cells are seeded on micropost arrays in order to quantify their contractile behavior are becoming increasingly common. Interpretation of the data generated by this experimental technique is ... -
A Study of Microstructure-Sensitive Crack Nucleation and Wear in Fretting
McCarthy, Oliver J. (2013-07-08)This thesis presents the development of a computational and experimental methodology for predicting crack initiation and wear in fretting of engineering materials. A bridge-type fretting fatigue test rig is designed and ... -
A thermodynamically motivated investigation of cell and tissue remodelling
McEvoy, Eóin (NUI Galway, 2018-08-24)The overall objective of this thesis is to provide a new understanding of the mechanisms that drive cell spreading and remodelling, and to extend this understanding to remodelling at a tissue and organ level. A steady-state ...