Browsing by Author "McFarland, John"
Now showing items 1-6 of 6
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Altered interhemispheric and temporal lobe white matter microstructural organization in severe chronic schizophrenia
Holleran, Laurena; Ahmed, Mohamed; Anderson-Schmidt, Heike; McFarland, John; Emsell, Louise; Leemans, Alexander; Scanlon, Cathy; Dockery, Peter; McCarthy, Peter; Barker, Gareth J; McDonald, Colm; Cannon, Dara M. (Springer Nature, 2013-10-22)Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left frontal and ... -
Cognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery.
Kenney, Joanne; Anderson-Schmidt, Heike; Scanlon, Cathy; Arndt, Sophia; Scherz, Elisabeth; McInerney, Shane; McFarland, John; Byrne, Fintan; Ahmed, Mohamed; Donohoe, Gary; Hallahan, Brian; McDonald, Colm; Cannon, Dara M. (2015-09-26)While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of ... -
Comparing temporal event-coding in patients with first episode psychosis and chronic schizophrenia
Schmidt, Heike; McFarland, John; McDonald, Colm; Elliott, Mark (Elsevier, 2008-06)Cognitive impairments are a core feature of schizophrenia. It has been suggested that the underlying cause of the cognitive deficits in schizophrenia is an impaired ability to sequence mental activity in time. Various ... -
Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome.
Scanlon, Cathy; Anderson-Schmidt, Heike; McInerney, Shane; Kenney, Joanne; McFarland, John; Waldron, Mairead; Ambati, Srinath; Fullard, Anna; Logan, Sam; Hallahan, Brian; Elliott, Mark A.; Cannon, Dara M.; McDonald, Colm (Elsevier, 2014-08-11)First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may ... -
Low-level temporal coding impairments in psychosis: Preliminary findings and recommendations for further studies.
Schmidt, Heike; McFarland, John; Ahmed, Mohamed; Elliott, Mark (American Psychological AssociationThis article may not exactly replicate the final version published in the APA journal. It is not the copy of record, 2011)We investigated whether difficulties with temporal event-coding, previously reported in patients with schizophrenia, are already present during first-episode psychosis (FEP). In this experiment, the subjective judgements ... -
Progressive brain atrophy and cortical thinning in schizophrenia after commencing clozapine treatment
Ahmed, Mohamed; Cannon, Dara M.; Scanlon, Cathy; Holleran, Laurena; Schmidt, Heike; McFarland, John; Langan, Camilla; McCarthy, Peter; Barker, Gareth J; Hallahan, Brian; McDonald, Colm (Springer Nature, 2015-04-01)Despite evidence that clozapine may be neuroprotective, there are few longitudinal magnetic resonance imaging (MRI) studies that have specifically explored an association between commencement of clozapine treatment for ...