Browsing by Author "Maher, Majella"
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Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women
Sedano-Balbás, Sara; Lyons, Mark; Cleary, Brendan; Murray, Margaret; Gaffney, Geraldine; Maher, Majella (2011)The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated ... -
APCR, factor V gene known and novel SNPs and adverse pregnancy outcomes in an Irish cohort of pregnant women
Sedano-Balbás, Sara; Lyons, Mark; Cleary, Brendan; Murray, Margaret; Gaffney, Geraldine; Maher, Majella (2010)Background: Activated Protein C Resistance (APCR), a poor anticoagulant response of APC in haemostasis, is the commonest heritable thrombophilia. Adverse outcomes during pregnancy have been linked to APCR. This study ... -
Apcr, factor v gene known and novel snps and adverse pregnancy outcomes in an irish cohort of pregnant women
Sedano-Balbás, Sara; Lyons, Mark; Cleary, Brendan; Murray, Margaret; Gaffney, Geraldine; Maher, Majella (Springer Nature, 2010-03-10)Background: Activated Protein C Resistance (APCR), a poor anticoagulant response of APC in haemostasis, is the commonest heritable thrombophilia. Adverse outcomes during pregnancy have been linked to APCR. This study ... -
Detection of nasba amplified bacterial tmrna molecules on slicsel designed microarray probes
Scheler, Ott; Kaplinski, Lauris; Glynn, Barry; Palta, Priit; Parkel, Sven; Toome, Kadri; Maher, Majella; Barry, Thomas; Remm, Maido; Kurg, Ants (Springer Nature, 2011-01-01)Background: We present a comprehensive technological solution for bacterial diagnostics using tmRNA as a marker molecule. A robust probe design algorithm for microbial detection microarray is implemented. The probes were ... -
Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens
Maher, Majella; Glennon, Maura; Smith, Terry; Dawson, Michael T. (ACM, 1996-06-18)We report on a PCR-based assay we have developed for the detection of Mycobacterium tuberculosis in sputum samples. One hundred sputum specimens, which included 34 culture-positive and 66 culture-negative specimens, were ... -
Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs.
Wernecke, Martina; Mullen, Ciara; Sharma, Vimla; Morrison, John; Barry, Thomas; Maher, Majella; Smith, Terry (2009)Despite the implementation of prevention guidelines, early-onset group B streptococci (GBS) disease remains a cause of neonatal morbidity and mortality worldwide. Strategies to identify women who are at risk of transmitting ... -
Evaluation of a novel real-time pcr test based on the ssragene for the identification of group b streptococci in vaginal swabs
Wernecke, Martina; Mullen, Ciara; Sharma, Vimla; Morrison, John; Barry, Thomas; Maher, Majella; Smith, Terry (Springer Nature, 2009-09-04)Background: Despite the implementation of prevention guidelines, early-onset group B streptococci (GBS) disease remains a cause of neonatal morbidity and mortality worldwide. Strategies to identify women who are at risk ... -
Evaluation of taxa-specific real-time pcr, whole-cell fish and morphotaxonomy analyses for the detection and quantification of the toxic microalgae alexandrium minutum (dinophyceae), global clade ribotype
Touzet, Nicolas; Keady, Evelyn; Raine, Robin; Maher, Majella (Oxford University Press (OUP), 2009-02-01)The dinoflagellate genus Alexandrium contains neurotoxin-producing species that have adversely affected the aquaculture industry in many countries. The morphological similarity between Alexandrium species has led to the ... -
Fluorescent labeling of NASBA amplified tmRNA molecules for microarray applications
Glynn, Barry; Maher, Majella (2009)BACKGROUND: Here we present a novel promising microbial diagnostic method that combines the sensitivity of Nucleic Acid Sequence Based Amplification (NASBA) with the high information content of microarray technology for ... -
Fluorescent labeling of nasba amplified tmrna molecules for microarray applications
Scheler, Ott; Glynn, Barry; Parkel, Sven; Palta, Priit; Toome, Kadri; Kaplinski, Lauris; Remm, Maido; Maher, Majella; Kurg, Ants (Springer Nature, 2009-01-01)Background: Here we present a novel promising microbial diagnostic method that combines the sensitivity of Nucleic Acid Sequence Based Amplification (NASBA) with the high information content of microarray technology for ... -
Integrated microfluidic tmrna purification and real-time nasba device for molecular diagnostics
Dimov, Ivan K.; Garcia-Cordero, Jose L.; O'Grady, Justin; Poulsen, Claus R.; Viguier, Caroline; Kent, Lorcan; Daly, Paul; Lincoln, Bryan; Maher, Majella; O'Kennedy, Richard; Smith, Terry J.; Ricco, Antonio J.; Lee, Luke P. (Royal Society of Chemistry (RSC), 2008-01-01)We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection. The real-time amplification and detection step produces ... -
Novel Multiplex Real-Time PCR Diagnostic Assay for Identification and Differentiation of Mycobacterium tuberculosis, Mycobacterium canettii, and Mycobacterium tuberculosis Complex Strains
Reddington, Kate; O'Grady, Justin; Dorai-Raj, Siobhan; Maher, Majella; van Soolingen, Dick; Barry, Thomas (Journal of Clinical Microbiology, 2011-02)Tuberculosis (TB) in humans is caused by members of the Mycobacterium tuberculosis complex (MTC). Rapid detection of the MTC is necessary for the timely initiation of antibiotic treatment, while differentiation between ... -
Rapid real-time pcr detection of listeria monocytogenes in enriched food samples based on the ssra gene, a novel diagnostic target
O’ Grady, Justin; Sedano-Balbás, Sara; Maher, Majella; Smith, Terry; Barry, Thomas (Elsevier BV, 2008-02-01) -
Real-time pcr detection of dinophysis species in irish coastal waters
Kavanagh, Siobhán; Brennan, Claire; O’Connor, Louise; Moran, Siobhán; Salas, Rafael; Lyons, Josephine; Silke, Joe; Maher, Majella (Springer Nature, 2009-11-28)Diarrhetic shellfish toxin-producing Dinophysis species occur in Irish coastal waters throughout the year. Dinophysis acuta and Dinophysis acuminata are the most commonly occurring species and are responsible for the ... -
Tmrna â a novel high-copy-number rna diagnostic target â its application forstaphylococcus aureusdetection using real-time nasba
O'Grady, Justin; Lacey, Katrina; Glynn, Barry; Smith, Terry J.; Barry, Thomas; Maher, Majella (Oxford University Press (OUP), 2009-12-01)A real-time nucleic acid sequence-based amplification assay, targeting tmRNA, was designed for the rapid identification of Staphylococcus aureus. The selectivity of the assay was confirmed against a panel of 76 Staphylococcus ...