Browsing by Author "Lowndes, Noel Francis"
Now showing items 1-4 of 4
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A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
Moureau, Sylvie; Luessing, Janna; Harte, Emma Christina; Voisin, Muriel; Lowndes, Noel Francis (The Royal Society, 2016-09-01)Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions. Here, we provide evidence supporting a ... -
Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
De Castro Abreu, Carla Manuela (2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
Characterisation of novel ATM-interacting factors involved in double-strand break repair
Pessina, Fabio (2012-10-22)Ataxia-telangiectasia (A-T) is a rare human disease characterized by cerebellar degeneration, immune system defects and cancer predisposition. The disease has been the subject of intense scientific scrutiny, particularly ... -
Modification of histones by sugar β-n-acetylglucosamine (glcnac) occurs on multiple residues, including histone h3 serine 10, and is cell cycle-regulated
Zhang, Suisheng; Roche, Kevin; Nasheuer, Heinz-Peter; Lowndes, Noel Francis (American Society for Biochemistry & Molecular Biology (ASBMB), 2011-09-06)The monosaccharide, beta-N-acetylglucosamine (GlcNAc), can be added to the hydroxyl group of either serines or threonines to generate an O-linked beta-N-acetylglucosamine (O-GlcNAc) residue (Love, D. C., and Hanover, J. ...