Browsing by Author "Lowndes, Noel"
Now showing items 1-8 of 8
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Analysis of the DNA damage response in model systems
Hamilton, Danielle (2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
ATR mediated regulation of the abscission checkpoint
Okowa, Chituru (NUI Galway, 2018-05-30)Unperturbed mitotic cell division is essential for survival. For cells to complete mitosis, genetic material must be distributed equally between the new cells before the final abscission. Failure to complete chromosome ... -
ATR prevents cells entering mitosis with excess unreplicated DNA and is required for the Abscission Checkpoint
Harte, Emma (2014-08-15)Maintaining genome integrity is an essential requirement for cells and a tightly regulated DNA damage response (DDR) is required to maintain viability of the cell and prevent disease. ATM and ATR are key regulators in ... -
Characterisation of novel Histone H3 RAD9 mutants defective in the DNA damage response in Saccharomyces cerevisiae
Walsh, Mary (2013-02-28)The DNA damage response (DDR) is a signal transduction cascade, which regulates cell cycle progression, gene transcription and DNA repair. Histones also play a vital role in the activation of the DDR and have been shown ... -
The kinesin KIF18B interacts with 53BP1 and is required for efficient double strand break repair
Frizzell, Louise (2015-11-19)Genetic changes can lead to detrimental genomic instability, mutagenesis, oncogenesis and premature aging. The DNA damage response (DDR) is responsible for safeguarding the genome from such harmful alterations. 53BP1 ... -
RNA metabolism proteins identified as ATM and 53BP1 partners function in the DDR
Luessing, Janna (2017-07-05)The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ... -
Role of Rad9 cell cycle phosphorylation in the regulation of Chk1 activation
Kumar, Ramesh (2012-01-07)DNA damage checkpoints are triggered in response to DNA insults. Once activated, these pathways prevent replication and segregation of the damaged DNA. In addition to cell cycle delays they regulate repair, transcription ... -
The mrn complex
Rupnik, Agnieszka; Grenon, Muriel; Lowndes, Noel (Elsevier BV, 2008-06-01)