Browsing by Author "Logue, Susan E."

Now showing items 1-5 of 5

    • Disruption of microrna biogenesis confers resistance to er stress-induced cell death upstream of the mitochondrion 

      Cawley, Karen; Logue, Susan E.; Gorman, Adrienne M.; Zeng, Qingping; Patterson, John; Gupta, Sanjeev; Samali, Afshin (Public Library of Science (PLoS), 2013-08-19)
      Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ...

    • Endoplasmic reticulum stress-mediated induction of sestrin 2 potentiates cell survival 

      Saveljeva, Svetlana; Cleary, Patricia; Mnich, Katarzyna; Ayo, Abiodun; Pakos-Zebrucka, Karolina; Patterson, John B.; Logue, Susan E.; Samali, Afshin (Impact Journals, LLC, 2016-02-22)
      Upregulation of SESTRIN 2 (SESN2) has been reported in response to diverse cellular stresses. In this study we demonstrate SESTRIN 2 induction following endoplasmic reticulum (ER) stress. ER stress-induced increases in ...

    • Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization 

      Gupta, Sanjeev; Cuffe, Lorraine; Szegezdi, Eva; Logue, Susan E.; Neary, Catherine; Healy, Sandra; Samali, Afshin (2010)
      During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ...

    • RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells 

      Jaafar, Rola; Mnich, Katarzyna; Dolan, Sarah; Hillis, Jennifer; Almanza, Aitor; Logue, Susan E.; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2018-02-06)
      Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ...

    • The janus face of death receptor signaling during tumor immunoediting 

      O’ Reilly, Eimear; Tirincsi, Andrea; Logue, Susan E.; Szegezdi, Eva (Frontiers Media SA, 2016-10-31)
      Cancer immune surveillance is essential for the inhibition of carcinogenesis. Malignantly transformed cells can be recognized by both the innate and adaptive immune systems through different mechanisms. Immune effector ...