Browsing by Author "Kerr, DM"
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Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions
Burke, N.N.; Hayes, E; Calpin, P; Kerr, DM; Moriarty, Orla; Finn, David P.; Roche, Michelle (2010)Altered pain responding in depression is a widely recognized but poorly understood phenomenon The present study investigated nociceptive responding to acute (thermal and mechanical) and persistent (inflammatory) noxious ... -
The monoacylglycerol lipase inhibitor jzl184 attenuates lps-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action
Kerr, DM; Harhen, B; Okine, BN; Egan, LJ; Finn, David P.; Roche, M (Wiley-Blackwell, 2013-05-27)Background and purpose JZL184 is a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme that preferentially catabolizes the endocannabinoid 2-arachidonoyl glycerol (2-AG). Here, we have studied the effects of ...