Browsing by Subject "Hydrogel"
Now showing items 1-5 of 5
-
Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels
(SAGE Publications, 2018-10-25)Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical ... -
Elastin-like recombinamers-based hydrogel modulates the post-ischemic remodelling in a clinically-relevant model of myocardial infarction
(NUI Galway, 2019-04-17)Myocardial infarction (MI) belongs to the family of cardiovascular diseases and represents the primary cause of worldwide mortality. Despite the promising results achieved in both small and large animal studies, recent ... -
Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ... -
Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
(Elsevier, 2020-03-04)The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ... -
Towards an optimal microenvironment for nucleus pulposus regeneration: a glycobiology approach
(2013-04-11)Neck and low back pain are the two highest causes of job-related disability in the UK and the USA. These pathologies are strongly related to intervertebral disc degeneration (IVD). Disc degeneration diseases (DDD) are ...