Browsing by Author "Higgins, Brendan D."
Now showing items 1-8 of 8
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A comparison of the glidescope®, pentax aws®, and macintosh laryngoscopes when used by novice personnel: a manikin study
Malik, Muhammad A.; Hassett, Patrick; Carney, John; Higgins, Brendan D.; Harte, Brian H.; Laffey, John G. (Springer Nature, 2009-08-05)Purpose Direct laryngoscopic tracheal intubation is a potentially lifesaving procedure, but a difficult skill to acquire and maintain. The consequences of poorly performed intubation attempts are potentially severe. The ... -
Aerosol-mediated delivery of aav2/6-iκbα attenuates lipopolysaccharide-induced acute lung injury in rats
MacLoughlin, Ronan J.; Higgins, Brendan D.; Devaney, James; O'Toole, Daniel; Laffey, John G.; O'Brien, Timothy (Mary Ann Liebert Inc, 2015-01-01)Inhibition of the proinflammatory transcription factor NF-kappa B has previously been shown to attenuate the inflammatory response in tissue after injury. However, the feasibility and efficacy of aerosolized adeno-associated ... -
Comparison of the Airtraq® and Truview® laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins
Nasim, Sajid; Butt, Ihsan; Malik, Muhammad A.; O' Donnell, John; Higgins, Brendan D.; Harte, Brian H.; Laffey, John G. (2009)Background Paramedics are frequently required to perform tracheal intubation, a potentially life-saving manoeuvre in severely ill patients, in the prehospital setting. However, direct laryngoscopy is often more difficult ... -
Comparison of the Glidescope® and Pentax AWS® laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation
Nasim, Sajid; Maharaj, Chrisen H.; Malik, Muhammad A.; O' Donnell, John; Higgins, Brendan D.; Laffey, John G. (2009)Background Intubation of the trachea in the pre-hospital setting may be lifesaving in severely ill and injured patients. However, tracheal intubation is frequently difficult to perform in this challenging environment, is ... -
Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis
Higgins, Brendan D.; Costello, Joseph; Contreras, Maya; Hassett, Patrick; Oʼ Toole, Daniel; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2009-12-01)Background: Acute lyypercapnic acidosis protects against lung injury caused by nonseptic insults and after both pulmonary and systemic sepsis. The authors wished to dissect the contribution of the acidosis versus hypercapnia ... -
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Maharaj, Chrisen H.; O'Toole, Daniel; Lynch, Tadhg; Carney, John; Jarman, James; Higgins, Brendan D.; Morrison, John J.; Laffey, John G. (2009)Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ... -
Hypercapnia and acidosis in sepsis
Curley, Gerard; Contreras, Maya; Nichol, Alistair D.; Higgins, Brendan D.; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2010-02-01)Acute respiratory distress syndrome is a devastating disease that causes substantial morbidity and mortality. Mechanical ventilation can worsen lung injury, whereas ventilatory strategies that reduce lung stretch, resulting ... -
Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia
Chonghaile, Martina Ni; Higgins, Brendan D.; Costello, Joseph; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2008-11-01)Background: Hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. The effects of hypercapnic acidosis in the setting of established pulmonary ...