Browsing by Author "Hickey, Rita"
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Exploitation of spr to investigate the importance of glycan chains in the interaction between lactoferrin and bacteria
O’Riordan, Noelle; Kilcoyne, Michelle; Joshi, Lokesh; Hickey, Rita (MDPI AG, 2017-06-27)Bovine lactoferrin (LF) has been shown to prevent adhesion to and invasion of mammalian cell lines by pathogenic bacteria, with evidence for direct bacterial binding by the milk glycoprotein. However, the glycosylation ... -
Glycomacropeptide reduces intestinal epithelial cell barrier dysfunction and adhesion of entero-hemorrhagic and entero-pathogenic escherichia coli in vitro
Feeney, Shane; Ryan, Joseph; Kilcoyne, Michelle; Joshi, Lokesh; Hickey, Rita (MDPI AG, 2017-10-27)In recent years, the potential of glycosylated food components to positively influence health has received considerable attention. Milk is a rich source of biologically active glycoconjugates which are associated with ... -
The influence of milk oligosaccharides on host-commensal interactions in the GI tract
Kavanaugh, Devon (2013-11)This thesis sets out to explore the influence of milk oligosaccharides on the colonisation of the intestinal microflora and their potential downstream impact upon components of the gastrointestinal tract. Milk oligosaccharides ... -
Mining milk for factors which modulate host-microbial interactions in vitro
Quinn, Erinn Marie (NUI Galway, 2021-02-03)Human milk oligosaccharides (HMO) have been reported to increase the adhesion of Bifidobacterium longum subsp. infantis ATCC 15697 (B. infantis ATCC 15697) to human colonic adenocarcinoma, HT-29 cells. In this thesis, ... -
Targeting the glycome of major milk proteins
O'Riordan, Noelle (2016-10-20)The objectives of this thesis were to 1) explore the glycosylation of major bovine milk proteins, 2) investigate the effect of lactational stage on glycan structures and 3) examine how these documented changes may influence ...