Browsing by Author "Healy, Sandra"
Now showing items 1-2 of 2
-
A high through-put screen for small molecules modulating mcm2 phosphorylation identifies ryuvidine as an inducer of the dna damage response
FitzGerald, Jennifer; Murillo, Laura S.; O'Brien, Gemma; O'Connell, Enda; O'Connor, Aisling; Wu, Kevin; Wang, Guan-Nan; Rainey, Michael D.; Natoni, Alessandro; Healy, Sandra; O'Dwyer, Michael; Santocanale, Corrado (Public Library of Science (PLoS), 2014-06-05)DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has ... -
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
Gupta, Sanjeev; Cuffe, Lorraine; Szegezdi, Eva; Logue, Susan E.; Neary, Catherine; Healy, Sandra; Samali, Afshin (2010)During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ...