Browsing by Author "Griffin, Matthew D."
Now showing items 1-20 of 38
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Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Alagesan, Senthilkumar; Sanz‐Nogués, Clara; Chen, Xizhe; Creane, Michael; Ritter, Thomas; Ceredig, Rhodri; O'Brien, Timothy; Griffin, Matthew D. (Wiley, 2018-02-15)Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ... -
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: Are we still learning?
Lohan, Paul; Treacy, Oliver; Griffin, Matthew D.; Ritter, Thomas; Ryan, Aideen E. (Frontiers Media, 2017-11-24)Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ... -
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: are we still learning?
Lohan, Paul; Treacy, Oliver; Griffin, Matthew D.; Ritter, Thomas; Ryan, Aideen E. (Frontiers Media SA, 2017-11-24)Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ... -
Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe
Griffin, Tomás P.; O'Shea, Paula M.; Smyth, Andrew; Islam, Md Nahidul; Wall, Deirdre; Ferguson, John; O'Sullivan, Esther; Finucane, Francis M.; Dinneen, Sean F.; Dunne, Fidelma P.; Lappin, David W.; Reddan, Donal N.; Bell, Marcia; O'Brien, Timothy; Griffin, Damian G.; Griffin, Matthew D. (BMJ Publishing Group, 2021-06-14)Introduction This study aimed to determine the prevalence of diabetic kidney disease (DKD) and rapid renal function decline and to identify indices associated with this decline among adults attending a diabetes center in ... -
Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?
Griffin, Matthew D.; Elliman, Stephen J.; Cahill, Emer; English, Karen; Ceredig, Rhodri; Ritter, Thomas (Wiley-Blackwell, 2013-10-01)Mesenchymal stromal (stem) cells (MSCs) continue to be a strong area of focus for academic- and industry-based researchers who share the goal of expanding their therapeutic use for diverse inflammatory and immune-mediated ... -
Defective neutrophil rolling and transmigration in acute uremia
Pindjakova, Jana; Griffin, Matthew D. (Elsevier BV, 2011-09-01)Circulating neutrophils are essential for innate immunity and undergo rapid, stepwise adhesion to and transmigration through the endothelium following tissue injury and microbial invasion. Neutrophil dysfunction may ... -
Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD).
Hamon, Siobhan M.; Griffin, Tomás P.; Islam, Md Nahidul; Wall, Deirdre; Griffin, Matthew D.; O’Shea, Paula M. (De Gruyter, 2018-09-15)BACKGROUND: Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative ... -
Dendritic cells facilitate accumulation of il-17t cells in the kidney following acute renal obstruction
Dong, Xiangyang; Bachman, Lori A.; Miller, Melinda N.; Nath, Karl A.; Griffin, Matthew D. (Elsevier BV, 2008-11-01)Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) ... -
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
Cabral, Joana; Hanley, Shirley A.; Gerlach, Jared Q.; O’Leary, Neil; Cunningham, Stephen; Ritter, Thomas; Ceredig, Rhodri; Joshi, Lokesh; Griffin, Matthew D. (Frontiers Media SA, 2017-08-21)Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ... -
Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury
McNicholas, Bairbre A.; Griffin, Matthew D. (Elsevier BV, 2012-06-01)Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of ... -
Editorial: Innovative biologics and drugs to target renal inflammation
Griffin, Matthew D.; Swaminathan, Sundararaman (Frontiers Media, 2020-02-06)[No abstract available] -
Effect of sodium glucose co-transporter-2 inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus
Griffin, Tomás P.; Islam, Md Nahidul; Blake, Liam; Bell, Marcia; Griffin, Matthew D.; O’Shea, Paula M. (Thieme Publishing, 2018-12-06)The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of ... -
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
Negi, Neema; Griffin, Matthew D. (AlphaMed Press and Wiley, 2020-01-29)The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T cells (T-reg) is well recognized by translational scientists in the field of regenerative medicine and cellular therapies. A wide range ... -
Extracellular vesicles as modulators of wound healing
Cabral, Joana; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Elsevier, 2018-01-31)Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been ... -
First responders: understanding monocyte-lineage traffic in the acutely injured kidney
Swaminathan, Sundararaman; Griffin, Matthew D. (Elsevier BV, 2008-12-01)Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between ... -
The glycosylation signature of human urinary extracellular vesicles
Krueger, Anja (2015-12-22)Cells of virtually all organs and tissues are known to release large numbers of subcellular particles called extracellular vesicles (EVs) into bodily fluids such as blood and urine. There has been a growing interest in ... -
High-risk corneal transplantation: Recent developments and future possibilities
Armitage, W. John; Goodchild, Christine; Griffin, Matthew D.; Gunn, David J.; Hjortdal, Jesper; Lohan, Paul; Murphy, Conor C.; Pleyer, Uwe; Ritter, Thomas; Tole, Derek M.; Vabres, Bertrand (Lippincott, Williams & Wilkins, 2019-12)Human corneal transplantation (keratoplasty) is typically considered to have superior short- and long-term outcomes and lower requirement for immunosuppression compared to solid organ transplants because of the inherent ... -
Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers
Islam, Md Nahidul; Griffin, Tomás P.; Sander, Elizabeth; Rocks, Stephanie; Qazi, Junaid; Cabral, Joana; McCaul, Jasmin; McMorrow, Tara; Griffin, Matthew D. (BMC, 2019-11-19)Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ... -
Human monocyte subset distinctions and function: Insights from gene expression analysis
Cormican, Sarah; Griffin, Matthew D. (Frontiers Media, 2020-06-04)Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing ... -
Identification and characterization of kidney transplants with good glomerular filtration rate at 1 year but subsequent progressive loss of renal function
Park, Walter D.; Larson, Timothy S.; Griffin, Matthew D.; Stegall, Mark D. (Ovid Technologies (Wolters Kluwer Health), 2012-11-01)Background. After the first year after kidney transplantation, 3% to 5% of grafts fail each year but detailed studies of how grafts progress to failure are lacking. This study aimed to analyze the functional stability of ...