Browsing by Author "Grealy, Maura"
Now showing items 1-7 of 7
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09-p080 effects of plakophilin 2 knockdown on zebrafish embryonic development
Moriarty, Miriam A.; Byrnes, Lucy; Grealy, Maura (Elsevier BV, 2009-08-01) -
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
Lynskey, Tracy (NUI Galway, 2018-12-14)Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ... -
Desmosomal armadillo proteins in zebrafish cardiac development
Ryan, Rebecca (2012-12-18)Plakoglobin and plakophilin-2 are desmosomal armadillo proteins, required for correct cardiac development in zebrafish. Mutations in the human genes can cause the congenital heart defect arrhythmogenic right ventricular ... -
Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos
Hartnett, Lori; Glynn, Catherine; Nolan, Catherine M.; Grealy, Maura; Byrnes, Lucy (UPV/EHU Press, 2010-01-01)The insulin-like growth factor (IGF) family is essential for normal embryonic growth and development and it is highly conserved through vertebrate evolution. However, the roles that the individual members of the IGF family ... -
Loss of plakophilin 2 disrupts heart development in zebrafish
Moriarty, Miriam A.; Ryan, Rebecca; Lalor, Pierce; Dockery, Peter; Byrnes, Lucy; Grealy, Maura (UPV/EHU Press, 2012-01-01)The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. To investigate loss ... -
Plakoglobin has both structural and signalling roles in zebrafish development
Martin, Eva D.; Moriarty, Miriam A.; Byrnes, Lucy; Grealy, Maura (Elsevier BV, 2009-03-01) -
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
Cronin, Aileen (NUI Galway, 2018-04-06)Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ...