Browsing by Author "Frizzell, Aisling"
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Histone deacetylase complexes as caretakers of genome stability
Lahue, Robert S.; Frizzell, Aisling (Informa UK Limited, 2012-08-18) -
Mutsβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
Gannon, Anne-Marie M.; Frizzell, Aisling; Healy, Evan; Lahue, Robert S. (Oxford University Press (OUP), 2012-08-30)Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington's disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. ... -
Proteins that modulate trinucleotide repeat expansions in human cells
Frizzell, Aisling (2012-09-18)Expansions of trinucleotide repeats (TNRs) are the genetic cause of several inherited neurological diseases, such as Huntington's disease, myotonic dystrophy and fragile X syndrome. TNR diseases and their causal expansion ... -
Rtel1 inhibits trinucleotide repeat expansions and fragility
Frizzell, Aisling; Nguyen, Jennifer H.G.; Petalcorin, Mark I.R.; Turner, Katherine D.; Boulton, Simon J.; Freudenreich, Catherine H.; Lahue, Robert S. (Elsevier BV, 2014-03-01)Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure. Here, we show that RTEL1 also blocks trinucleotide repeat expansions, ...