Browsing by Author "FP6"
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Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
FitzGerald, Jennifer; Moureau, Sylvie; O'Connell, Enda; Grenon, Muriel; Muriel, Noel F. (PLoS, 2011-02)Background Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ... -
Revealing the Origin and Nature of Drug Resistance of Dynamic Tumour Systems
Santiago-Mozos, Ricardo; Khan, Imtiaz A.; Madden, Michael G. (2010)In this paper, the authors identify the strategies that resistant subpopulations of cancer cells undertake to overcome the effect of the anticancer drug Topotecan. For the analyses of cell lineage data encoded from timelapse ... -
Review of the Legal Framework Applicable to Marine Protected Areas as a Tool for Ecosystem Conservation & Fisheries Management
Long, Ronan (2006)This chapter reviews the legal basis in a number of international and European legal instruments underpinning the establishment of Marine Protected Areas (MPAs) as a tool for ecosystem conservation and fisheries ...