Browsing by Subject "ER stress"
Now showing items 1-8 of 8
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Identification and validation of novel targets of regulated IRE1-dependent decay in triple negative breast cancer
(NUI Galway, 2023-08-16)Breast cancer is the most commonly diagnosed cancer in women. Triple-negative breast cancer (TNBC) refers to a subtype which lacks oestrogen receptors (ESR1), progesterone receptors (PR) and does not overexpress Human ... -
Investigating the role of IRE1α RNase activity in breast cancer
(NUI Galway, 2018-12-17)Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ... -
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
(2015-09-18)X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress. Activation of the endoplasmic reticulum ... -
miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
(2014)Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ... -
The molecular characterization of ER stress-induced autophagy and cell death
(2012-12-21)Autophagy is tightly regulated by the unfolded protein response (UPR). It plays an important role in the removal of unfolded proteins, damaged mitochondria and expanded endoplasmic reticulum (ER), to help relieve ER stress ... -
The regulation of ER stress induced cell death by HSPB1 (hsp27)
(2013-01-29)Endoplasmic reticulum (ER) stress is associated with several human pathologies including neurodegenerative disorders. ER stress results in accumulation of unfolded proteins which activates the unfolded protein response ... -
The role of IRE1α in the regulation of cytokine production
(NUI Galway, 2020-04-16)Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ... -
The role of microRNAs during endoplasmic reticulum stress induced cell death
(2012-04-25)Endoplasmic Reticulum (ER) stress occurs in response to negative insult or stimuli to the cell. It induces a pathway called the unfolded protein response (UPR) which can alleviate stress and restore the cell to its ¿healthy ...