Browsing by Author "Duffy, Michelle M."
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Immunomodulation of the T-helper 17 Cell Lineage by Mesenchymal Stem Cells
Duffy, Michelle M. (2012-11-20)T-helper 17 (Th17) cells play a pathogenic role in multiple sclerosis, inflammatory bowel disease, psoriasis, acute kidney injury, glomerulonephritis and transplant rejection. Mesenchymal stem cells (MSCs) are immunosuppressive ... -
Interleukin-1 accounts for intrarenal th17 cell activation during ureteral obstruction
Pindjakova, Jana; Hanley, Shirley A.; Duffy, Michelle M.; Sutton, Caroline E.; Weidhofer, Gudrun A.; Miller, Melinda N.; Nath, Karl A.; Mills, Kingston H.G.; Ceredig, Rhodri; Griffin, Matthew D. (Elsevier BV, 2012-02-01)Interleukin 17A-secreting T-helper 17 (Th17) cells are pathogenic in inflammatory kidney diseases, but their intrarenal regulation is poorly understood. In order to better define Th17 cell dynamics during interstitial ... -
Mesenchymal stem cell inhibition of t-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin e2 via the ep4 receptor
Duffy, Michelle M.; Pindjakova, Jana; Hanley, Shirley A.; McCarthy, Cathal; Weidhofer, Gudrun A.; Sweeney, Eva M.; English, Karen; Shaw, Georgina; Murphy, J. Mary; Barry, Frank P.; Mahon, Bernard P.; Belton, Orina; Ceredig, Rhodri; Griffin, Matthew D. (Wiley-Blackwell, 2011-08-30)Mesenchymal stem cells (MSCs) inhibit T-cell activation and proliferation but their effects on individual T-cell-effector pathways and on memory versus naive T cells remain unclear. MSC influence on the differentiation of ...