Browsing by Subject "Drug delivery"
Now showing items 1-7 of 7
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Design and synthesis of biocompatible metal-organic frameworks for anti-cancer, anti-tubercular and MRI application
(NUI Galway, 2023-07-11)Metal-organic frameworks (MOFs) are relatively new porous materials that have attracted significant attention in recent decades. Potential applications in gas storage and separation have been at the forefront of this ... -
Developing reservoir systems for therapeutic delivery of biomolecules to a degenerated disc
(2015-01-05)Low back pain has severe consequences for the quality of life of the affected patients and strong evidence suggests that this condition is caused by degeneration of the intervertebral disc (IVD). Disc degeneration coincides ... -
Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform
(Nature Research, 2022-08-03)Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal ... -
In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations
(Elsevier, 2020-04-08)Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen ... -
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
(Elsevier, 2019-06-19)The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ... -
Mathematical Analysis of Some Models for Drug Delivery
(2012-08-27)This thesis is concerned with the mathematical modelling of controlled drug release from a number of delivery systems. There are two major strands to the work: (i) modelling release from affinity-based systems, and, (ii) ... -
Replicating and modulating skin fibrosis in vitro: Multi-compartment collagen devices as dual drug delivery vehicles
(NUI Galway, 2022-01-10)Complex pathologies, such as fibrosis, are often not the result of a singular event, but rather the consequence of multiple disruptions in the normal balance between intricately connected organs, tissues and signalling ...