Browsing by Author "Deegan, Shane"
Now showing items 1-6 of 6
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A new microfluidic approach for the one-step capture, amplification and label-free quantification of bacteria from raw samples
Pereiro, Iago; Bendali, Amel; Tabnaoui, Sanae; Alexandre, Lucile; Srbova, Jana; Bilkova, Zuzana; Deegan, Shane; Joshi, Lokesh; Viovy, Jean-Louis; Malaquin, Laurent; Dupuy, Bruno; Descroix, Stéphanie (Royal Society of Chemistry (RSC), 2017-01-01)A microfluidic method to specifically capture and detect infectious bacteria based on immunorecognition and proliferative power is presented. It involves a microscale fluidized bed in which magnetic and drag forces are ... -
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under er stress conditions
Deegan, Shane; Saveljeva, Svetlana; Logue, Susan E; Pakos-Zebrucka, Karolina; Gupta, Sanjeev; Vandenabeele, Peter; Bertrand, Mathieu JM; Samali, Afshin (Informa UK Limited, 2014-11-02)Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and ... -
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
Gupta, Sanjeev; Deepti, Ayswaria; Deegan, Shane; Samali, Afshin (2010)Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ... -
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ... -
The molecular characterization of ER stress-induced autophagy and cell death
Deegan, Shane (2012-12-21)Autophagy is tightly regulated by the unfolded protein response (UPR). It plays an important role in the removal of unfolded proteins, damaged mitochondria and expanded endoplasmic reticulum (ER), to help relieve ER stress ... -
Noxa contributes to the sensitivity of perk-deficient cells to er stress
Gupta, Sanjeev; Giricz, Zoltan; Natoni, Alessandro; Donnelly, Neysan; Deegan, Shane; Szegezdi, Eva; Samali, Afshin (Wiley-Blackwell, 2012-10-12)