Browsing by Subject "DNA repair"
Now showing items 1-15 of 15
-
Analysis of the DNA damage response in model systems
(2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
Cep164-null cells generated by genome editing show a ciliation defect with intact dna repair capacity
(The Company of Biologists, 2016-03-10)Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium ... -
Characterisation of novel ATM-interacting factors involved in double-strand break repair
(2012-10-22)Ataxia-telangiectasia (A-T) is a rare human disease characterized by cerebellar degeneration, immune system defects and cancer predisposition. The disease has been the subject of intense scientific scrutiny, particularly ... -
Expansions of CAG·CTG repeats in immortalized human astrocytes.
(Oxford University Press, 2007)Expansions of trinucleotide repeats (TNRs) are the genetic cause for a number of neurodegenerative disorders. In some of these diseases, ongoing somatic expansions in the brain are thought to contribute to disease progression. ... -
Functional dissection of the Smc5/6 complex: roles of the SUMO ligase Nse2/Mms21 in the maintenance of genome stability
(2011-06)Nse2/ Mms21 is an E3 SUMO ligase component of the Smc5/6 complex, which plays multiple roles in maintaining genome stability. To study the functions of the vertebrate Nse2 orthologue, we generated Nse2-deficient chicken ... -
Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells
(Wiley-Blackwell, 2014-07-15)Mesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor ... -
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01) -
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
(Springer, 2008)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion ... -
Multiple facets of the dna damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines
(Wiley-Blackwell, 2012-12-19)The regeneration of the hematopoietic system following total body irradiation is supported by host-derived mesenchymal stromal cells (MSCs) within the bone marrow. The mechanisms used by MSCs to survive radiation doses ... -
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae
(OUP, 2008)Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to several hundred nucleotides in bacteria, yeast and human cells, and ... -
Regulation and function of the tumour suppressor 53BP1 at sites of DNA damage
(2013-10-16)Cancer is the major cause of death for people in middle age. It results from cell transformation into malignant cells and propagates with normal controls. This process is induced by mutations occurring in DNA through the ... -
The response of mouse mesenchymal stromal cells to radiation-induced DNA double-strand breaks
(2013-12-16)Mesenchymal stromal cells (MSCs) are radio-resistant stem cell progenitors that support haematopoiesis in the bone marrow and contribute to the tumour microenvironment. The mechanisms that drive MSC radio-resistance are ... -
A role for USP9X in homologous recombination repair of DNA double strand breaks
(NUI Galway, 2020-02-11)In order to prevent the deleterious effects of a variety of genotoxic agents, cells have developed complex surveillance mechanisms and multiple DNA repair pathways that allow them to maintain genome integrity. The ... -
The roles of centrins/caltractins at the centrosome and in genome maintenance
(2012-06-21)The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ... -
Trinucleotide repeat expansions catalyzed by human cell-free extracts
(Springer Nature, 2013-01-22)Trinucleotide repeat expansions cause 17 heritable human neurological disorders. In some diseases, somatic expansions occur in non-proliferating tissues such as brain where DNA replication is limited. This finding stimulated ...