Browsing by Subject "Cytokines"
Now showing items 1-9 of 9
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Alkoxyalkyl esters of nucleotide analogs inhibit polyomavirus DNA replication and large T antigen activities
(American Society for Microbiology Journals, 2020-12-07)Polyomavirus-related infections are ubiqutious in immunocompromised individuals and in some cases are intractable and fatal. Due to lack of approved drugs to treat polyomavirus infections, cidofovir, a phosphonate nucleotide ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
(2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Characterization of post-traumatic immunosuppression and its partial reversal by autologous salvaged blood transfusion
(2015-01-28)Documentary evidence of post-traumatic immunosuppression (PTI) is traceable back to 1856. Although improved hygiene has ameliorated many risks, vulnerability to systemic infection following major surgery or closed injury ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
(Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ... -
Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment
(National Academy of Sciences, 2016-11-04)Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating ... -
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
(Elsevier, 2017-02-22)Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ... -
Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action
(2013)Background and purpose: This study determined the effect of JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme which preferentially catabolises the endocannabinoid 2-arachidonoyl glycerol (2-AG), ...