Browsing by Author "Curran, Catherine"

Now showing items 1-10 of 10

    • A germline mutation in the brca13’utr predicts stage iv breast cancer 

      Dorairaj, Jemima J; Salzman, David W; Wall, Deirdre; Rounds, Tiffany; Preskill, Carina; Sullivan, Catherine AW; Lindner, Robert; Curran, Catherine; Lezon-Geyda, Kim; McVeigh, Terri; Harris, Lyndsay; Newell, John; Kerin, Michael J; Wood, Marie; Miller, Nicola; Weidhaas, Joanne B (Springer Nature, 2014-06-10)
      Background: A germline, variant in the BRCA1 3'UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. ...

    • Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics 

      Kheirelseid, Elrasheid A. H.; Jumustafa, Hanzali; Miller, Nicola; Curran, Catherine; Sweeney, Karl; Malone, Carmel; McLaughlin, Ray; Newell, John; Kerin, Michael J. (Springer Nature, 2010-07-28)
      There has been conflicting evidence on the impact of bilateral breast cancer (BBC) on the survival and management of patients. The objectives of this study were to address the incidence of BBC and to investigate its ...

    • Differential impact of hormone receptor status on survival and recurrence for her2 receptor-positive breast cancers treated with trastuzumab 

      McGuire, Andrew; Kalinina, Olga; Holian, Emma; Curran, Catherine; Malone, Carmel A.; McLaughlin, Ray; Lowery, Aoife; Brown, James A. L.; Kerin, Michael J. (Springer Nature, 2017-04-04)
      Introduction Hormone receptor status has major implications for treatment and survival of breast cancer. Yet the impact of hormone receptor status on outcome after Trastuzumab has received little attention. The objective ...

    • Erratum to: the tgfbr1*6a/9a polymorphism is not associated with differential risk of breast cancer 

      Colleran, Gabrielle; McInerney, Niall; Rowan, Andrew; Barclay, Ella; Jones, Angela M.; Curran, Catherine; Miller, Nicola; Kerin, Michael; Tomlinson, Ian; Sawyer, Elinor (Springer Nature, 2011-03-29)

    • Low penetrance breast cancer predisposition snps are site specific 

      Mcinerney, Niall; Colleran, Gabrielle; Rowan, Andrew; Walther, Axel; Barclay, Ella; Spain, Sarah; Jones, Angela M.; Tuohy, Stephen; Curran, Catherine; Miller, Nicola; Kerin, Michael; Tomlinson, Ian; Sawyer, Elinor (Springer Nature, 2008-11-13)
      Large scale association studies have identified low penetrance susceptibility alleles that predispose to breast cancer. A locus on chromosome 8q24.21 has been shown to harbour variants that predispose to breast, ovarian, ...

    • Microrna-10a is reduced in breast cancer and regulated in part through retinoic acid 

      Khan, Sonja; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J; Dwyer, Róisín M. (Springer Nature, 2015-05-02)
      Background: MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. MicroRNA-10a ...

    • miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...

    • Mir-379 regulates cyclin b1 expression and is decreased in breast cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O’Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (Public Library of Science (PLoS), 2013-07-10)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...

    • The effect of menopause and hysterectomy on systemic vascular endothelial growth factor in women undergoing surgery for breast cancer 

      Lowery, Aoife J; Sweeney, Karl J; Molloy, Alan P; Hennessy, Emer; Curran, Catherine; Kerin, Michael J (Springer Nature, 2008-09-30)
      Background: Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine produced physiologically by the uterus. Pathological secretion by tumours promotes growth and metastasis. High circulating VEGF levels ...

    • Younger age as a prognostic indicator in breast cancer: a cohort study 

      Kheirelseid, Elrasheid AH; Boggs, Jennifer ME; Curran, Catherine; Glynn, Ronan W; Dooley, Cara; Sweeney, Karl J; Kerin, Michael J (Springer Nature, 2011-08-28)
      Background: The debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of ...