Browsing by Author "Contreras, Maya"
Now showing items 1-5 of 5
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Clinical review: gene-based therapies for ali/ards: where are we now?
Devaney, James; Contreras, Maya; Laffey, John G (Springer Nature, 2011-01-01)Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) confer substantial morbidity and mortality, and have no specific therapy. The accessibility of the distal lung epithelium via the airway route, and the ... -
Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis
Higgins, Brendan D.; Costello, Joseph; Contreras, Maya; Hassett, Patrick; Oʼ Toole, Daniel; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2009-12-01)Background: Acute lyypercapnic acidosis protects against lung injury caused by nonseptic insults and after both pulmonary and systemic sepsis. The authors wished to dissect the contribution of the acidosis versus hypercapnia ... -
Evolution of the inflammatory and fibroproliferative responses during resolution and repair after ventilator-induced lung injury in the rat
Curley, Gerard F.; Contreras, Maya; Higgins, Brendan; OʼKane, Cecilia; McAuley, Daniel F.; OʼToole, Daniel; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2011-11-01)Background: The time course and mechanisms of resolution and repair, and the potential for fibrosis following ventilation-induced lung injury (VILI), are unclear. We sought to examine the pattern of inflammation, injury, ... -
Hypercapnia and acidosis in sepsis
Curley, Gerard; Contreras, Maya; Nichol, Alistair D.; Higgins, Brendan D.; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2010-02-01)Acute respiratory distress syndrome is a devastating disease that causes substantial morbidity and mortality. Mechanical ventilation can worsen lung injury, whereas ventilatory strategies that reduce lung stretch, resulting ... -
Investigation of the Role of the NF-kB Pathway in Mediating the Effects of Hypercapnic Acidosis in Prolonged Systemic Sepsis and Ventilation Induced Acute Lung Injury
Contreras, Maya (2012-11)Background: Lung protective ventilation is integral to the management of ARDS. The resulting respiratory acidosis [HCA], termed 'permissive hypercapnia', is protective in diverse non-septic acute lung injury [ALI] models, ...