Browsing by Subject "Colorectal cancer"

Now showing items 1-7 of 7

    • Clinical Applications of Molecular Profiling in Colorectal Cancer 

      Kheirelseid, Elrasheid Ahmed Hassan (2011-06)
      Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ...

    • Combining biological and chemical approaches in marine biodiscovery 

      Firsova, Daria (2017-06-13)
      Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical ecology, chemical ...

    • Exosomal microRNAs in colorectal cancer 

      Clancy, Cillian (2016)
      Cancer cells have been shown to release a variety of extracellular membrane vesicles including microvesicles known as exosomes. Exosomes have recently been found to contain microRNAs (miRNAs) however the full range within ...

    • Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation 

      Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)
      Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...

    • MicroRNA expression in colorectal cancer. 

      Hogan, Niamh M.; Joyce, Myles R. (IOS Press, 2012-12-17)
      Colorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth ...

    • The role of sialylation in stromal cell-mediated immunosuppression in the colorectal tumour microenvironment 

      Egan, Hannah (NUI Galway, 2023-04-19)
      Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of many immunotherapies. The hypersialylation of cancer cells contributes significantly to this suppressive environment, aiding in tumour immune ...

    • Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment 

      Fitzgerald, Seán; Espina, Virginia; Liotta, Lance; Sheehan, Katherine M.; O’Grady, Anthony; Cummins, Robert; O’Kennedy, Richard; Kay, Elaine W.; Kijanka, Gregor S. (BMC (part of Springer Nature), 2018-04-10)
      Background Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription ...