Browsing by Subject "Cisplatin"
Now showing items 1-2 of 2
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Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ... -
Effects of proteasome inhibition on cisplatin induced DNA damage responses in human cells
(2012-02-07)The proteasome is the main site of protein degradation in human cells, and plays a major role in the regulation of cellular processes including cell cycle progression, DNA repair and the DNA damage response. Proteasome ...