Browsing by Author "Chen, Xizhe"
Now showing items 1-8 of 8
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A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction
Flynn, Aidan; Chen, Xizhe; O'Connell, Enda; O'Brien, Timothy (Springer Nature, 2012-01-01)Introduction: A number of questions remain unanswered in the field of cell therapy for acute myocardial infarction, including what is the optimal cell type, and can therapeutic efficacy be enhanced by conditioning regimens. ... -
Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Alagesan, Senthilkumar; Sanz‐Nogués, Clara; Chen, Xizhe; Creane, Michael; Ritter, Thomas; Ceredig, Rhodri; O'Brien, Timothy; Griffin, Matthew D. (Wiley, 2018-02-15)Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ... -
Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation
Ryan, Aideen E; Lohan, Paul; O'Flynn, Lisa; Treacy, Oliver; Chen, Xizhe; Coleman, Cynthia; Shaw, Georgina; Murphy, Mary; Barry, Frank; Griffin, Matthew D; Ritter, Thomas (Elsevier BV, 2014-03-01)Allogeneic mesenchymal stem cells (allo-MSCs) have potent regenerative and immunosuppressive potential and are being investigated as a therapy for osteoarthritis; however, little is known about the immunological changes ... -
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
Dash, Biraja C.; Thomas, Dilip; Monaghan, Michael; Carroll, Oliver; Chen, Xizhe; Woodhouse, Kimberly; O'Brien, Timothy; Pandit, Abhay (Elsevier, 2015-10)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ... -
Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold
Holladay, Carolyn A.; Duffy, Aoife M.; Chen, Xizhe; O'Brien, Timothy; Pandit, Abhay (2011-11)Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects. This may be related to poor survival of the transplanted ... -
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ... -
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
Lynch, Kevin; Treacy, Oliver; Chen, Xizhe; Murphy, Nick; Lohan, Paul; Islam, Md Nahidul; Donohoe, Ellen; Griffin, Matthew D.; Watson, Luke; McLoughlin, Steven; O'Malley, Grace; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2020-05-29)Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ... -
The pre-conditioning of unrestricted somatic stem cells alters their genotype, but does not enhance their ability to repair cardiac damage
Flynn, Aidan; Chen, Xizhe; O'Connell, Enda; Barry, Frank; O'Brien, Timothy (Elsevier BV, 2011-04-01)