Browsing by Author "Ceredig, Rhodri"
Now showing items 1-20 of 35
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A stromal cell free culture system generates mouse pro-t cells that can reconstitute t-cell compartments in vivo
Gehre, Nadine; Nusser, Anja; von Muenchow, Lilly; Tussiwand, Roxane; Engdahl, Corinne; Capoferri, Giuseppina; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley-Blackwell, 2014-12-16)T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture ... -
Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Alagesan, Senthilkumar; Sanz‐Nogués, Clara; Chen, Xizhe; Creane, Michael; Ritter, Thomas; Ceredig, Rhodri; O'Brien, Timothy; Griffin, Matthew D. (Wiley, 2018-02-15)Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ... -
Bone marrow stromal cell transplantation ameliorates cytopenias caused by depletion of FAP-α expressing cells
Camarillo Retamosa, Eva (NUI Galway, 2018-05-03)Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflammatory diseases as phase 3 clinical trials have demonstrated. However, the en-dogenous roles of stromal cells (SSCs) are ... -
Characterization of post-traumatic immunosuppression and its partial reversal by autologous salvaged blood transfusion
Islam, Nahidul (2015-01-28)Documentary evidence of post-traumatic immunosuppression (PTI) is traceable back to 1856. Although improved hygiene has ameliorated many risks, vulnerability to systemic infection following major surgery or closed injury ... -
Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?
Griffin, Matthew D.; Elliman, Stephen J.; Cahill, Emer; English, Karen; Ceredig, Rhodri; Ritter, Thomas (Wiley-Blackwell, 2013-10-01)Mesenchymal stromal (stem) cells (MSCs) continue to be a strong area of focus for academic- and industry-based researchers who share the goal of expanding their therapeutic use for diverse inflammatory and immune-mediated ... -
Development and optimization of an egfp-based reporter for measuring the general stress response inlisteria monocytogenes
Utratna, Marta; Cosgrave, Eoin; Baustian, Claas; Ceredig, Rhodri; O’Byrne, Conor (Informa UK Limited, 2012-03-01)A characteristic of the food-borne pathogen Listeria monocytogenes is its tolerance to the harsh conditions found both in minimally processed foods and the human gastrointestinal tract. This trait is partly under the control ... -
Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells
Ribeiro, Andreia; Ritter, Thomas; Griffin, Matthew; Ceredig, Rhodri (Elsevier, 2016-07-20)Human bone marrow-derived mesenchymal stromal/stem cells (MSC) have well-documented modulatory effects on multiple immune cell types. Although these effects are linked to their therapeutic benefit in diverse diseases, a ... -
Differential response of mouse thymic epithelial cell types to ionizing radiation-induced dna damage
Calvo-Asensio, Irene; Barthlott, Thomas; von Muenchow, Lilly; Lowndes, Noel F.; Ceredig, Rhodri (Frontiers Media SA, 2017-04-13)Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic ... -
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
Cabral, Joana; Hanley, Shirley A.; Gerlach, Jared Q.; O’Leary, Neil; Cunningham, Stephen; Ritter, Thomas; Ceredig, Rhodri; Joshi, Lokesh; Griffin, Matthew D. (Frontiers Media SA, 2017-08-21)Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ... -
Dn2 thymocytes activate a specific robust dna damage response to ionizing radiation-induced dna double-strand breaks
Calvo-Asensio, Irene; Sugrue, Tara; Bosco, Nabil; Rolink, Antonius; Ceredig, Rhodri (Frontiers Media SA, 2018-06-11)For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it ... -
Effects of hypoxia on the response of the haematopoietic system to radiation-induced DNA damage
Calvo Asensio, Irene (2017-05-09)Preparative regimens using DNA damaging agents such as total body irradiation (TBI) prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system including the stromal cells that ... -
Graft-versus-host disease: who's responsible?
Ceredig, Rhodri (Springer Nature, 2011-07-12) -
Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells
Sugrue, Tara; Lowndes, Noel F.; Ceredig, Rhodri (Wiley-Blackwell, 2014-07-15)Mesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor ... -
Interleukin-1 accounts for intrarenal th17 cell activation during ureteral obstruction
Pindjakova, Jana; Hanley, Shirley A.; Duffy, Michelle M.; Sutton, Caroline E.; Weidhofer, Gudrun A.; Miller, Melinda N.; Nath, Karl A.; Mills, Kingston H.G.; Ceredig, Rhodri; Griffin, Matthew D. (Elsevier BV, 2012-02-01)Interleukin 17A-secreting T-helper 17 (Th17) cells are pathogenic in inflammatory kidney diseases, but their intrarenal regulation is poorly understood. In order to better define Th17 cell dynamics during interstitial ... -
Investigation of intron coevolution and the autoimmune potential of alternative splicing
Keane, Peter (2016-07-20)Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ... -
An investigation of the immunometabolic interactions of obesity
Dennedy, Michael Conall (2013-09-04)Human monocytes are classified as classical, intermediate and non-classical according to their surface expression of CD14 and CD16. They also represent precursors to atherogenic foam cells and macrophages in metabolically ... -
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
Baustian, Claas; Hanley, Shirley; Ceredig, Rhodri (Springer Nature, 2015-08-25)Introduction: Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, ... -
Lymanalyzer: a tool for comprehensive analysis of next generation sequencing data of t cell receptors and immunoglobulins
Yu, Yaxuan; Ceredig, Rhodri; Seoighe, Cathal (Oxford University Press (OUP), 2015-10-07)The adaptive immune system includes populations of B and T cells capable of binding foreign epitopes via antigen specific receptors, called immunoglobulin (IG) for B cells and the T cell receptor (TCR) for T cells. In order ... -
Mesenchymal stem cell effects on t-cell effector pathways
Duffy, Michelle M; Ritter, Thomas; Ceredig, Rhodri; Griffin, Matthew D (Springer Nature, 2011-01-01)Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the functions of immune cells, including T ... -
Mesenchymal stem cell inhibition of t-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin e2 via the ep4 receptor
Duffy, Michelle M.; Pindjakova, Jana; Hanley, Shirley A.; McCarthy, Cathal; Weidhofer, Gudrun A.; Sweeney, Eva M.; English, Karen; Shaw, Georgina; Murphy, J. Mary; Barry, Frank P.; Mahon, Bernard P.; Belton, Orina; Ceredig, Rhodri; Griffin, Matthew D. (Wiley-Blackwell, 2011-08-30)Mesenchymal stem cells (MSCs) inhibit T-cell activation and proliferation but their effects on individual T-cell-effector pathways and on memory versus naive T cells remain unclear. MSC influence on the differentiation of ...