Browsing by Author "Breslin, Loretta"
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Centrosome amplification in cho and dt40 cells by inactivation of cyclin-dependent kinases
Steere, Nathan; Wagner, Michael; Beishir, Stephen; Smith, Ewan; Breslin, Loretta; Morrison, Ciaran G.; Hochegger, Helfrid; Kuriyama, Ryoko (Wiley-Blackwell, 2011-07-29) -
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
Breslin, Loretta; Prosser, Suzanna L; Cuffe, Sandra; Morrison, Ciaran G (Informa UK Limited, 2014-09-02)Somatic cells senesce in culture after a finite number of divisions indefinitely arresting their proliferation. DNA damage and senescence increase the cellular number of centrosomes, the 2 microtubule organizing centers ... -
The primary cilium as a regulator of cellular senescence in human fibroblasts
Breslin, Loretta (2014-02-11)Somatic cells senesce in culture after a finite number of divisions, indefinitely arresting their proliferation. Among the major causes of senescence is persistent DNA damage signalling. DNA damage and senescence increase ...