Browsing by Author "Boyd, Aoife"
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Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
Boyd, Aoife (American Society for Microbiology, 2008-01)Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ... -
Competition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE
Boyd, Aoife (American Society for Microbiology, 2000-09)A type III secretion-translocation system allows Yersinia adhering at the surface of animal cells to deliver a cocktail of effector Yops (YopH, -O, -P, -E, -M, and -T) into the cytosol of these cells. Residues or codons 1 ... -
The effects of Vibrio parahaemolyticus on Mitogen Activated Protein Kinase signalling pathways and intestinal epithelial host cell responses
Finn, Rebecca (2013-02-20)Vibrio parahaemolyticus is a gram negative bacterium that is found in marine and estuarine environments. Although found amongst the commensal flora of shellfish, V. parahaemolyticus is a potent human pathogen. Consumption ... -
Functional screening of human faecal microbiome metagenome library for glycoside hydrolase enzymes
Mulualem, Daniel (NUI Galway, 2020-04-24)Members of the human gut microbiota use glycoside hydrolase (GH) enzymes, such as sialidases, α-fucosidases and β-galactosidases to forage on host mucin glycans and dietary fibers. A human faecal metagenomic library was ... -
Identification and characterisation of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
Agbavwe, Christy (2017-03-24)Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ... -
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
Boyd, Aoife; Abram, Florence; Karatzas, Kimon-andreas; Matlawska-Wasowska, Ksenia; Connolly, David; O'Byrne, Conor P.; Starr, Emily (American Society for Microbiology, 2008-09)Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ... -
In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex
Tonoyan, Lilit; Boyd, Aoife; Fleming, Gerard T.A.; Friel, Ruairi; Gately, Carol M.; Mc Cay, Paul H.; O'Flaherty, Vincent (Elsevier, 2018-04-03)Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate ... -
Investigation of pathogenic vibrio in Irish aquaculture
Boyle, Katie Louise (NUI Galway, 2023-07-31)Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae are marine pathogens that cause gastroenteritis in humans after the consumption of infected shellfish. Vibrio can cause devastating losses of oysters, shrimps ... -
LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells
Boyd, Aoife (American Society for Microbiology, 1998-06)Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of ... -
Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus
O'Boyle, Nicky; Boyd, Aoife (Frontiers Media, 2014-01-10)Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells ... -
Manipulation of intestinal epithelial cell function by the cell contact-dependent type iii secretion systems of vibrio parahaemolyticus
O'Boyle, Nicky; Boyd, Aoife (Frontiers Media SA, 2014-01-01)Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells ... -
The molecular mechanisms governing the colonisation of intestinal epithelial cells by Vibrio parahaemolyticus
O Boyle, Nicholas (2012-12-19)Vibrio parahaemolyticus is a food borne gastro-intestinal pathogen of major global importance. The organism induces severe inflammatory diarrhea in individuals who become infected due to the consumption of contaminated ... -
Pathogenic bacteria in our oceans' shellfish
Boyd, Aoife (Microbiology Society, 2019-02)Mussels, oysters, clams – some of the most appetising culinary dishes, such as moules-frites, feature shellfish. These foods are considered healthy as they are fresh from the ocean, but looks can be deceiving. -
Review of the Executive Masters in Business Administration (EMBA), National University of Ireland, Galway
Wood, Geoff; Beech, Nic; Broder, Fergal; Dempsey, Mary; Boyd, Aoife (NUI Galway, 2009-04-01)[No abstract available] -
Role of alginate lyase in cell detachment of Pseudomonas aeruginosa
Boyd, Aoife (American Society for Microbiology, 1994-07)The exopolysaccharide alginate of Pseudomonas aeruginosa was shown to be important in determining the degree of cell detachment from an agar surface. Nonmucoid strain 8822 gave rise to 50-fold more sloughed cells than ... -
Stress response and virulence of Vibrio vulnificus: role of the stressosome and secondary effects of antibiotic resistance
Cutugno, Laura (NUI Galway, 2021-12-22)Bacterial stress response and virulence are two key factors that guarantee the survival and propagation of pathogens. The elucidation of factors that affect these aspects in the human pathogen Vibrio vulnificus was the ... -
The vibrio parahaemolyticus type iii secretion systems manipulate host cell mapk for critical steps in pathogenesis
Matlawska-Wasowska, Ksenia; Finn, Rebecca; Mustel, Ana; O'Byrne, Conor P; Baird, Alan W; Coffey, Eleanor T; Boyd, Aoife (Springer Nature, 2010-01-01)Background: Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type III Secretion Systems (TTSS) that deliver effector ... -
Translocation ofvibrio parahaemolyticusacross anin vitrom cell model
Finn, Rebecca; Ahmad, Tauseef; Coffey, Eleanor T.; Brayden, David J.; Baird, Alan W.; Boyd, Aoife (Oxford University Press (OUP), 2013-11-21)Consumption of Vibrio parahaemolyticus via contaminated shellfish results in inflammatory gastroenteritis characterised by severe diarrhoea, nausea and stomach cramps. This study investigated the translocation of ... -
The Vibrio parahaemolyticus ToxRS Regulator Is Required for Stress Tolerance and Colonization in a Novel Orogastric Streptomycin-Induced Adult Murine Model
Boyd, Aoife (American Society for Microbiology, 2012-03)Vibrio parahaemolyticus, a marine bacterium, is the causative agent of gastroenteritis associated with the consumption of seafood. It contains a homologue of the toxRS operon that in V. cholerae is the key regulator of ... -
The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis
Matlawska-Wasowska, Ksenia; Finn, Rebecca; Mustel, Ana; O'Byrne, Conor P.; Boyd, Aoife (BioMed Central, 2011)Background:Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type III Secretion Systems (TTSS) that deliver effector ...