Browsing by Author "Barry, Frank"
Now showing items 1-20 of 43
-
361. lentiviral vector transduction efficiency and biosafety profile of adult mesenchymal stem cells
McGrath, Barry M.; O'Shea, Ciara; Howard, Linda; Murphy, Mary; Barry, Frank; O'Brien, Timothy; Strappe, Padraig M. (Elsevier BV, 2006-01-01) -
A horse of a different color
Ranera, Beatriz; Barry, Frank (Wiley-Blackwell, 2014-06-20) -
Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase i dose-escalation trial
Pers, Yves-Marie; Rackwitz, Lars; Ferreira, Rosanna; Pullig, Oliver; Delfour, Christophe; Barry, Frank; Sensebe, Luc; Casteilla, Louis; Fleury, Sandrine; Bourin, Philippe; Noël, Danièle; Canovas, François; Cyteval, Catherine; Lisignoli, Gina; Schrauth, Joachim; Haddad, Daniel; Domergue, Sophie; Noeth, Ulrich; Jorgensen, Christian; , (Wiley-Blackwell, 2016-05-23)Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study ... -
Allogeneic murine mesenchymal stem cells: migration to inflamed joints in vivo and amelioration of collagen induced arthritis when transduced to express ctla4ig
Sullivan, Catherine; Barry, Frank; Ritter, Thomas; O'Flatharta, Cathal; Howard, Linda; Shaw, Georgina; Anegon, Ignacio; Murphy, Mary (Mary Ann Liebert Inc, 2013-12-15)Despite the immunosuppressive, homing, and regenerative capabilities of mesenchymal stem cells (MSCs), their ability to migrate to arthritic joints and influence the course of arthritis in vivo remains poorly understood. ... -
Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by erk-mediated enhancement of hif-1α activity
Fábián, Zsolt; Ramadurai, Sivaramakrishnan; Shaw, Georgina; Nasheuer, Heinz-Peter; Kolch, Walter; Taylor, Cormac; Barry, Frank (Elsevier BV, 2014-05-01) -
Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
Sadasivan, Saraswathi (2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
Xu, Maojia; Stattin, Eva-Lena; Shaw, Georgina; Heinegård, Dick; Sullivan, Gareth; Wilmut, Ian; Colman, Alan; Önnerfjord, Patrik; Khabut, Areej; Aspberg, Anders; Dockery, Peter; Hardingham, Timothy; Murphy, Mary; Barry, Frank (Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation
Ryan, Aideen E; Lohan, Paul; O'Flynn, Lisa; Treacy, Oliver; Chen, Xizhe; Coleman, Cynthia; Shaw, Georgina; Murphy, Mary; Barry, Frank; Griffin, Matthew D; Ritter, Thomas (Elsevier BV, 2014-03-01)Allogeneic mesenchymal stem cells (allo-MSCs) have potent regenerative and immunosuppressive potential and are being investigated as a therapy for osteoarthritis; however, little is known about the immunological changes ... -
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
Leszczynska, Aleksandra; O'Doherty, Aideen; Farrell, Eric; Pindjakova, Jana; O'Brien, Fergal J.; O'Brien, Timothy; Barry, Frank; Murphy, Mary (Wiley, 2016-02-27)The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ... -
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
Leszczynska, Aleksandra; O'Doherty, Aideen; Farrell, Eric; Pindjakova, Jana; O'Brien, Fergal J.; O'Brien, Timothy; Barry, Frank; Murphy, Mary (Wiley-Blackwell, 2016-02-27)The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ... -
Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury
Curley, Gerard F.; Ansari, Bilal; Hayes, Mairead; Devaney, James; Masterson, Claire; Ryan, Aideen; Barry, Frank; O’Brien, Timothy; Toole, Daniel O’; Laffey, John G. (Ovid Technologies (Wolters Kluwer Health), 2013-04-01)Background: Mesenchymal stromal cells (MSCs) have been demonstrated to attenuate acute lung injury when delivered by intravenous or intratracheal routes. The authors aimed to determine the efficacy of and mechanism of ... -
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
Barron, Valerie; Merghani, Khalid; Shaw, Georgina; Coleman, Cynthia; Hayes, Jessica; Ansboro, Sharon; Manian, Abi; O'Malley, Grace; Connolly, Emma; Nandakumar, Ananda; Van Blitterswijk, Clemen; Habibovic, Pamela; Moroni, Lorenzo; Shannon, Fintan; Barry, Frank; Murphy, Mary (Springer Verlag, 2015-01-15)The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ... -
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
Xu, Maojia (NUI Galway, 2019-02-15)The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ... -
Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model
Barron, Valerie; Neary, Martin; Mohamed, Khalid Merghani Salid; Ansboro, Sharon; Shaw, Georgina; O'Malley, Grace; Rooney, Niall; Barry, Frank; Murphy, Mary (Springer Verlag, 2015-10-05)Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ... -
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
Sharif, Faisal; Hynes, Sean O; Cooney, Ronan; Howard, Linda; McMahon, Jill; Daly, Kieran; Crowley, James; Barry, Frank; O'Brien, Timothy (Elsevier BV, 2008-10-01)Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ... -
Generation of induced pluripotent stem cells (aro-ipsc1-11) from a patient with autosomal recessive osteopetrosis harboring the c.212 + 1g > t mutation in snx10 gene
Xu, Maojia; Stattin, Eva-lena; Murphy, Mary; Barry, Frank (Elsevier BV, 2017-10-01) -
Genetic mismatch affects the immunosuppressive properties of mesenchymal stem cells in vitro and their ability to influence the course of collagen-induced arthritis
Sullivan, Catherine; Murphy, J Mary; Griffin, Matthew D; Porter, Ryan M; Evans, Christopher H; O'Flatharta, Cathal; Shaw, Georgina; Barry, Frank (Springer Nature, 2012-01-01)Introduction: The immunological and homing properties of mesenchymal stem cells (MSCs) provide a potentially attractive treatment for arthritis. The objective of this study was to determine effects of genetic disparity on ... -
Genetically Modified Mesenchymal Stem
Griffin, Matthew; Greiser, Udo; Barry, Frank; O'Brien, Timothy; Ritter, Thomas (2010-03)Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the ... -
Glycosaminoglycan Dependent Isolation of Mesenchymal Chondroprogenitor Populations from Human Bone Marrow
O'Sullivan, Janice (2013-01-24)Osteoarthritis (OA) is a chronic disease of joints characterised by progressive destruction of articular cartilage resulting in painful, limited joint movement. Cartilage has a limited ability to self-repair due to low ... -
Growth differentiation factor-5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophy
Coleman, Cynthia M.; Vaughan, Erin E.; Browe, David C.; Mooney, Emma; Howard, Linda; Barry, Frank (Mary Ann Liebert Inc, 2013-07-01)The regenerative potential for adult bone marrow-derived mesenchymal stromal cells (MSCs) has been extensively investigated in the setting of arthritic disease and focal cartilage defects. In vitro chondrogenic differentiation ...