Browsing by Subject "AML"
Now showing items 1-4 of 4
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Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
(NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Generation of natural killer cell-mimic nanoparticles to target tumour cells
(NUI Galway, 2022-05-30)Natural killer (NK) cells are effector immune cells in the innate immune system. It is increasingly recognised that NK cells play a crucial role eliminating emerging tumour cells. Some tumour cells however can escape and ... -
Mechanisms of bone marrow-mediated drug resistance in acute myeloid leukaemia
(NUI Galway, 2020-06-12)Acute myeloid leukaemia (AML) is a heterogenous clonal disorder characterised by the accumulation of immature, non-functional and highly proliferative blasts in the bone marrow and periphery. AML has a high relapse rate, ... -
The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis
(2011)Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents ...