Browsing by Subject "chemical toxicity"
Now showing items 1-2 of 2
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Electrochemiluminescence arrays for studies of metabolite-related toxicity
(Wiley-Blackwell, 2016-06-01)This article reviews recent progress from our laboratory in electrochemiluminescence (ECL) arrays designed for screening toxicity-related chemistry of chemical and drug candidates. Cytochrome P450s and metabolic bioconjugation ... -
Elucidating organ-specific metabolic toxicity chemistry from electrochemiluminescent enzyme/dna arrays and bioreactor bead-lc-ms/ms
(Royal Society of Chemistry (RSC), 2015-01-01)Human toxic responses are very often related to metabolism. Liver metabolism is traditionally studied, but other organs also convert chemicals and drugs to reactive metabolites leading to toxicity. When DNA damage is found, ...