Browsing by Subject "central spindle"
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Proteomic analysis of human metaphase chromosomes reveals topoisomerase ii alpha as an aurora b substrate
(Oxford University Press (OUP), 2002-12-01)The essential Aurora B kinase is a chromosomal passenger protein that is required for mitotic chromosome alignment and segregation. Aurora B function is dependent on the chromosome passenger, INCENP. INCENP, in turn, ... -
Sister chromatid cohesion and genome stability in vertebrate cells
(Portland Press Ltd., 2003-02-01)For successful eukaryotic mitosis, sister chromatid pairs remain linked after replication until their kinetochores have been attached to opposite spindle poles by microtubules. This linkage is broken at the metaphase-anaphase ...