Browsing by Subject "apaf-1 apoptosome"

Now showing items 1-5 of 5

    • Cd95-mediated alteration in hsp70 levels is dependent on protein stabilization 

      Concannon, Caoimhín G.; FitzGerald, Una; Holmberg, Carina I.; Szegezdi, Eva; Sistonen, Lea; Samali, Afshin (Springer Nature, 2005-01-01)
      Engagement of death receptors induces caspase activation and apoptosis. A recent study reported altered protein expression, including increased Hsp70 levels during CD95-mediated apoptosis. Here, we examined the mechanism ...

    • hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli 

      Samali, Afshin; Robertson, John D.; Peterson, Elisabeth; Manero, Florence; van Zeijl, Leone; Paul, Catherine; Cotgreave, Ian A.; Arrigo, André-Patrick; Orrenius, Sten (Springer Nature, 2001-01-01)
      Enhanced cell survival and resistance to apoptosis during thermotolerance correlates with an increased expression of heat shock proteins (Hsps). Here we present additional evidence in support of the hypothesis that the ...

    • Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis 

      Kennedy, Donna; Mnich, Katarzyna; Oommen, Deepu; Chakravarthy, Reka; Almeida-Souza, Leonardo; Krols, Michiel; Saveljeva, Svetlana; Doyle, Karen M.; Gupta, Sanjeev; Timmerman, Vincent; Janssens, Sophie; Gorman, Adrienne M.; Samali, Afshin (Springer Nature, 2017-08-31)
      BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ...

    • Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells 

      Moloney, Teresa C.; Hoban, Deirdre B.; Barry, Frank P.; Howard, Linda; Dowd, Eilís (Wiley-Blackwell, 2012-05-08)
      Although bone marrow-derived mesenchymal stem cells (MSCs) are an attractive cell therapy candidate, their potential is limited by poor survival following transplantation. Over-expression of anti-apoptotic heat shock ...

    • The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer 

      Malladi, Srinivas; Challa-Malladi, Madhavi; Fearnhead, Howard O; Bratton, Shawn B (Wiley-Blackwell, 2009-06-04)
      During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed ...