Browsing by Subject "actin cytoskeleton"
Now showing items 1-6 of 6
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Cell morphology and focal adhesion location alters internal cell stress
(The Royal Society, 2014-10-08)Extracellular mechanical cues have been shown to have a profound effect on osteogenic cell behaviour. However, it is not known precisely how these cues alter intracellular mechanics to initiate changes in cell behaviour. ... -
Design and formulation of functional pluripotent stem cell-derived cardiac microtissues
(Proceedings of the National Academy of Sciences, 2013-11-19)Access to robust and information-rich human cardiac tissue models would accelerate drug-based strategies for treating heart disease. Despite significant effort, the generation of high-fidelity adult-like human cardiac ... -
Expression of rhogtpase regulators in human myometrium
(Springer Nature, 2008-01-01)Background: RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), ... -
Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells
(Springer Nature, 2016-11-15)Background: Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ...