Browsing by Author "Basavaraju, Shivakumar"
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Centriole splitting caused by loss of the centrosomal linker protein c-nap1 reduces centriolar satellite density and impedes centrosome amplification
Flanagan, Anne-Marie; Stavenschi, Elena; Basavaraju, Shivakumar; Gaboriau, David; Hoey, David A.; Morrison, Ciaran G. (American Society for Cell Biology (ASCB), 2017-01-18)Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker ... -
Reverse genetic analysis of centrosomal roles of Checkpoint Kinase 1
Basavaraju, Shivakumar (NUI Galway, 2019-06-14)Centrosome duplication is tightly regulated process that occurs only once per cell cycle. Centrosome abnormalities have been observed in cancer cells and in cells with defective DNA damage responses. Genotoxic stresses ...