Browsing by Author "Apte, Simon H."

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    • Smg1 haploinsufficiency predisposes to tumor formation and inflammation 

      Roberts, Tara L.; Ho, Uda; Luff, John; Lee, C. Soon; Apte, Simon H.; MacDonald, Kelli P. A.; Raggat, Liza J.; Pettit, Allison R.; Morrow, Carl A.; Waters, Michael J.; Chen, Phil; Woods, Rick G.; Thomas, Gethin P.; St. Pierre, Liam; Farah, Camile S.; Clarke, Raymond A.; Brown, James A. L.; Lavin, Martin F. (Proceedings of the National Academy of Sciences, 2012-12-31)
      SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DNA-PK, proteins with known roles in DNA damage and cellular stress responses. SMG1 has a well-characterized role ...