Browsing by Author "Altman, Douglas G"

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    • Developing core outcome sets for clinical trials: issues to consider 

      Williamson, Paula R; Altman, Douglas G; Blazeby, Jane M; Clarke, Mike; Devane, Declan; Gargon, Elizabeth; Tugwell, Peter (Springer Nature, 2012-08-06)
      The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to influence ...

    • Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers 

      Cook, Jonathan A; ,; Hislop, Jenni; Altman, Douglas G; Fayers, Peter; Briggs, Andrew H; Ramsay, Craig R; Norrie, John D; Harvey, Ian M; Buckley, Brian; Fergusson, Dean; Ford, Ian; Vale, Luke D (Springer Nature, 2015-01-15)
      Background: Central to the design of a randomised controlled trial is the calculation of the number of participants needed. This is typically achieved by specifying a target difference and calculating the corresponding ...