Browsing by Title
Now showing items 2574-2593 of 14646
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A computational and experimental investigation of the dissection of arterial tissue
(NUI Galway, 2020-11-19)The overall objective of this thesis is to provide a new understanding of the mechanisms underlying arterial fracture, and to extend this understanding to the initiation and propagation of aortic dissection using a combination ... -
A computational and experimental investigation of the in-vivo biomechanics of the human aorta
(NUI Galway, 2020-07-06)The overall objective of this thesis is to provide a new understanding of the degree of biomechanical heterogeneity that exists along the human aorta, against the backdrop of clinical literature reporting that patient ... -
A computational and experimental investigation of tracheobronchial stent performance
(2017-05-25)Tracheobronchial stents are used to relieve blockages in the respiratory tree, typically caused by lung cancer. However, multiple complications can be associated with stents for this indication. In order to be able to ... -
Computational approaches to identify and explain sources of error in cancer somatic mutation data
(NUI Galway, 2024-04-18)Errors in the identification of somatic mutations in cancer samples can have critical implications in both research and clinical applications. Failure to detect potential variants of interest can lead to missed opportunities ... -
Computational design of glycomimetic inhibitors of Influenza A Adhesion
(2015-02-16)Many pathogens, such as avian influenza, Helicobacter pylori and Streptococcus pneumoniae, employ cell-surface glycans which terminate in Neu5AcAlpha(2-3)Gal as their adhesion partner.[1] As a result, a glycomimetic ... -
Computational development of a particle-In-cell computer code for the simulation of plasma Instabilities around rotation powered pulsars
(2014-09-03)This thesis reports on the design and development of DYMPHNA3D, a 3D particle-in-cell (PIC) plasma simulation code. It also focuses on the field of radio emission and the discovery of rotation powered neutron stars, ... -
Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan–protein complexes
(Elsevier BV, 2010-10-01)Modern computational methods offer the tools to provide insight into the structural and dynamic properties of carbohydrate-protein complexes beyond that provided by experimental structural biology Dynamic properties such ... -
Computational Homology of Cubical and Permutahedral Complexes
(2012-09-28)Homology is the study of connectivity and "holes" in spaces. The aim of this thesis is to introduce and develop a theory of permutahedral complexes for computations of homology of large data sets and to compare, using ... -
Computational homology of n-types
(2014-01-10)An n-type X is a CW-space with homotopy groups \pi_iX=0 for all i>n. Up to homotopy equivalence such a space can be specified algebraically by means of a simplicial group whose Moore complex is trivial in degrees >= n. For ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
A computational investigation of the laser bonding of balloon catheters
(2015-09-28)The balloon catheters produced by Boston Scientific are manufactured using a laser bonding process. The behaviour of the materials during this laser welding process is not very well understood. In this work a computational ... -
A computational investigation of the long-term performance of bioabsorbable magnesium-based implants in orthopaedic fracture applications
(NUI Galway, 2023-06-20)Current orthopaedic fixation devices made from stainless steel and titanium can lead to a range of long-term complications that include bone reabsorption due to stress shielding, implant loosening and/or infection. ... -
Computational methods for micromechanics characterisation: Application to and experimental investigation of metal additive manufacturing and heat treatment processes
(NUI Galway, 2022-11-23)Powder bed fusion (PBF) is an additive manufacturing process in which finely focused thermal energy is used to selectively melt target regions within thin layers of metal powders. Due to the complex thermal conditions ... -
Computational modelling framework for predicting the evolution of biodegradable polymers during degradation
(NUI Galway, 2022-11-28)Biodegradable polymers are attractive alternatives for many permanent implants, potentially reducing long term risks. Designing optimal devices for their intended purpose, however, is costly and time consuming, with small ... -
Computational modelling of dynamic recrystallisation of Ni-based superalloy during linear friction welding
(Springer, 2022-01-12)Linear friction welding (LFW) is an advanced joining technology used for manufacturing and repairing complex assemblies like blade integrated disks (blisks) of aeroengines. This paper presents an integrated multiphysics ... -
Computational modelling of emissions from gas turbines: Ensuring experimental reliability and quantifying emissions uncertainty
(NUI Galway, 2019-02-18)Global environmental concerns and the increasing amount of power generated using gas turbines have led to the development of dry low emission (DLE) combustion systems to minimize the NOx and CO pollutants. Improvements in ... -
Computational modelling of linear friction welding of Inconel 718
(NUI Galway, 2022-07-15)Linear friction welding (LFW) is a solid-state joining technique that involves the rapid reciprocating motion of two workpieces under large compressive pressure, in order to generate friction heat and plastically deformed ... -
Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ... -
Computational modelling of the coupled electro-mechanical behaviour of neurons
(NUI Galway, 2019-01-22)Recent experimental evidence has uncovered complex biophysical phenomena accompanying the electrical activity of nervous cells. Now emerging theories refer to the electric pulse, i.e. the Action Potential (AP), as an ...