Browsing by Title
Now showing items 2024-2043 of 14646
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Characterisation of human nucleolar organisers located in previously uncharted regions of the human genome
(NUI Galway, 2019-01-18)The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis. Nucleoli form around chromosomal loci called ‘nucleolar organiser regions (NORs) located on the short arms of the human acrocentric ... -
Characterisation of Irish-grown Scots pine timber for structural applications
(National University of Ireland Galway, 2020-08-27)There is very little knowledge on the timber quality of the native Scots pine grown in Ireland, and its potential to produce timber for structural applications. This paper studied the mechanical performance in tension and ... -
Characterisation of Irish-grown Scots pine timber for structural applications
(Civil Engineering Research in Ireland, 2020)There is very little knowledge on the timber quality of the native Scots pine grown in Ireland, and its potential to produce timber for structural applications. This paper studied the mechanical performance in tension and ... -
Characterisation of karst hydrogeology in western ireland using geophysical and hydraulic modelling techniques
(Elsevier BV, 2017-04-01) -
Characterisation of LCF performance of X100 weld-joints: Mechanistic yield strength modelling, finite element analyses and DIC testing
(Elsevier, 2021-03-26)This paper is concerned with the effect of welding on the fatigue behaviour of X100 material for steel catenary risers. The methodology includes both modelling and experimental characterisation. The modelling combines (i) ... -
Characterisation of novel ATM-interacting factors involved in double-strand break repair
(2012-10-22)Ataxia-telangiectasia (A-T) is a rare human disease characterized by cerebellar degeneration, immune system defects and cancer predisposition. The disease has been the subject of intense scientific scrutiny, particularly ... -
Characterisation of novel Histone H3 RAD9 mutants defective in the DNA damage response in Saccharomyces cerevisiae
(2013-02-28)The DNA damage response (DDR) is a signal transduction cascade, which regulates cell cycle progression, gene transcription and DNA repair. Histones also play a vital role in the activation of the DDR and have been shown ... -
Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
(Elsevier, 2016-12-01)The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling ... -
Characterisation of rotationally moulded polymer liners for low permeability cryogenic applications in composite overwrapped pressure vessels
(2016-09-20)Composite overwrapped pressure vessels (COPVs) have become a critical component in satellite and space applications due to their ability to store highly permeating fuels at high pressures and under cryogenic conditions. ... -
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ... -
Characterisation of the cellular responses to CDC7 inhibition in breast-derived human cells
(2017-10-06)CDC7 plays a role in DNA replication initiation and cell cycle regulation. Inhibition of CDC7 kinase by siRNA triggers a p53-independent apoptotic cell death in cancer cells but not in human fibroblast suggesting this ... -
Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)
(Elsevier, 2008-10-04)Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ... -
Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
(2016-07-01)Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ... -
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
(NUI Galway, 2019-12-16)The integrity of our genome is very important therefore, our cells have developed efficient DNA repair mechanisms to control this integrity and avoid mutations. Although the DNA double strand break response pathway is ... -
Characterisation of triple negative breast carcinoma and identification of the value of immunohistochemical markers and stromal tumour infiltrating lymphocytes
(NUI Galway, 2017-10)Breast cancer is a complex disease that encompasses multiple molecular subtypes that have different clinical behavior. The behavior can be influenced by both the characteristics of the cancer cells as well as the surrounding ... -
Characterisation of UVA-induced DNA damage responses in human skin cells
(2013-09-30)Accumulating evidence indicates that exposure to long-wavelength ultraviolet A (UVA) radiation (315-400 nm), which accounts for >95% of solar UV radiation reaching the earth's surface, is a significant risk factor for the ... -
Characterising and evaluating online communities from live microblogging user interactions
(NUI Galway, 2018-07-03)Microblogging (mainly represented by Twitter) is a type of social media that focuses on fast open real-time communication using short messages between users and their followers. This system is attractive due to its open ... -
Characterising bases of pure difference ideals
(NUI Galway, 2020-09-10)In this thesis, we study the basis sets of pure difference ideals, that is, ideals that are generated by differences of monic monomials. We examine the action of the hyperoctahedral group on the defining ideal of the Segre ... -
Characterising glyphosate exposures among amenity horticulturists using multiple spot urine samples
(Elsevier, 2018-07-08)Background Glyphosate has recently received much public attention following its Group 2A probably carcinogenic to humans classification from the International Agency for Research on Cancer. Despite the widespread ...