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Now showing items 1905-1924 of 14643
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CDC7 kinase promotes replication DNA double-strand breaks upon replication fork stalling and its inhibition causes an inflammatory response and senescence
(NUI Galway, 2022-12-08)CDC7 is an essential serine-threonine kinase that has an important role in the initiation of DNA replication. CDC7 phosphorylates several sites of the MCM helicase complex allowing recruitment of CDC45, among other factors, ... -
CDC7 kinase regulates DNA replication fork processing and its inhibition is modulated by PTBP1
(NUI Galway, 2022-09-21)CDC7 is an essential serine/threonine kinase that regulates the initiation of DNA replication by phosphorylating several sites of the MCM helicase complex. Several inhibitors of CDC7 are available that reduce cell proliferation ... -
Cdc7-dependent and -independent phosphorylation of claspin in the induction of the dna replication checkpoint
(Informa UK Limited, 2013-05-15)Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can ... -
Cdna and deduced amino acid sequence of thesalmo salar(atlantic salmon) adult hemoglobin alpha chain
(Oxford University Press (OUP), 1989-01-01) -
A cDNA microarray assessment of gene expression in the liver of rainbow trout (Oncorhynchus mykiss) in response to a handling and confinement stressor
(Elsevier, 2008-03)A purpose-designed microarray platform (Stressgenes, Phase 1) was utilised to investigate the changes in gene expression within the liver of rainbow trout during exposure to a prolonged period of confinement. Tissue and ... -
Cease agricultural activity forever? underestimating the importance of symbolic capital
(Elsevier BV, 2016-04-01) -
CEBus network access via the world-wide-web
(IEEE, 1996)Several methods of providing access to CEBus networks using the World Wide Web are described. Details of a working demonstration system are given. The system software incorporates CGI-Bin scripts and Java applets ... -
Cell complexes database for the Bianchi groups
(NUI Galway, 2016-05-18)This is a database of quotients by Bianchi groups of two-dimensional cellular equivariant retracts of Hyperbolic three-space. The Bianchi groups SL(2, A), with A the ring of integers in the imaginary quadratic number field ... -
Cell contact, prostaglandin e2and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of cd4+cd25highforkhead box p3+regulatory t cells
(Wiley-Blackwell, 2009-04-01)Adult human mesenchymal stromal or stem cells (MSC) can differentiate into a variety of cell types and are candidate cellular therapeutics in regenerative medicine. Surprisingly, these cells also display multiple potent ... -
Cell culture media analysis using rapid spectroscopic methods
(Elsevier, 2018-09-24)Cell culture media (CCM) used in industrial biotechnology are complex mixtures of molecules and elements that are inherently difficult to analyze comprehensively. CCM quality analysis is of utmost importance for efficient ... -
Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ... -
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage
(Wiley, 2013-08-02)The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the intra-S-phase checkpoint. Its interactions with other replication ... -
Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy
(Public Library of Science, 2012-04-19)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ... -
Cell cycle-dependent mobility of Cdc45 in living cells determined by fluorescence correlation spectroscopy.
(Public Library of Science, 2012)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ... -
Cell fate commitment during nervous system establishment: from stem cells to neurons
(NUI Galway, 2020-07-06)Members of the early-branching metazoan phylum of Cnidaria are well-recognized as a sister group to bilaterians making them an ideal candidate to study the evolution of the eumetazoan nervous system. I began to unravel the ... -
Cell morphology and focal adhesion location alters internal cell stress
(The Royal Society, 2014-10-08)Extracellular mechanical cues have been shown to have a profound effect on osteogenic cell behaviour. However, it is not known precisely how these cues alter intracellular mechanics to initiate changes in cell behaviour. ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
(2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Cell viability in three ex vivo rat models of spinal cord injury
(Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Cell wall evolution and diversity
(Frontiers Media SA, 2012-01-01)Plant cell walls display a considerable degree of diversity in their compositions and molecular architectures. In some cases the functional significance of a particular cell wall type appears to be easy to discern: secondary ...