Browsing by Title
Now showing items 1529-1548 of 14646
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A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
(NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
Biological applications of knowledge graph embedding models
(Oxford University Press (OUP), 2020-02-17)Complex biological systems are traditionally modelled as graphs of interconnected biological entities. These graphs, i.e. biological knowledge graphs, are then processed using graph exploratory approaches to perform different ... -
Biological characterization of a human mesenchymal stromal cell product
(2016-07-21)The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ... -
Biological characterization ofcampylobacter fetuslipopolysaccharides
(Oxford University Press (OUP), 1996-08-01)Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed ... -
Biological insights from 108 schizophrenia-associated genetic loci
(Springer Nature, 2014-07-22)Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ... -
Biological phosphorus removal during high-rate, low-temperature, anaerobic digestion of wastewater
(Frontiers Media, 2016-03-03)We report, for the first time, extensive biologically mediated phosphate removal from wastewater during high-rate anaerobic digestion (AD). A hybrid sludge bed/fixed-film (packed pumice stone) reactor was employed for ... -
Biological study of the angiogenesis inhibitor n-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin
(Wiley-Blackwell, 2010-06-01)The alpha-glucosidase inhibitors N-methyl-1-deoxynojirimycin (MDNJ) and castanospermine have been shown to inhibit angiogenesis. A hybrid of 1-deoxynojirimycin (DNJ) and an aryl-1,2,3-triazole, which inhibits both an ... -
The biology of the slug-killing Tetanocera elata (Diptera: Sciomyzidae) and its potential as a biological control agent for pestiferous slugs
(15-02-05)Laboratory experiments were carried out to determine the effects of controlled temperatures (14oC, 17oC, 20oC, 23oC, and 26oC) and ambient outdoor and laboratory temperatures on the development and predation capacity of ... -
Biomarkers: are realism and control mutually exclusive in integrated pollution assessment?
(Elsevier BV, 2014-12-01) -
A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
(The Royal Society, 2011-11)Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ... -
Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
(Public Library of Science (PLoS), 2013-06-03)Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ... -
Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
(2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives
(Wiley-Blackwell, 2016-02-03)Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical ... -
A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
(2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
(NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
A biomaterials approach to peripheral nerve repair
(2014-04-09)Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ... -
Biomedical semantic resources for drug discovery platforms
(Springer Verlag, 2017-11-08)The biomedical research community is providing large-scale data sources to enable knowledge discovery from the data alone, or from novel scientific experiments in combination with the existing knowledge. Increasingly ... -
Biometric access control for digital media streams in home networks
(IEEE, 2007)Methods for controlling access to digital media content in the home environment using biometric sensing techniques are described. A wireless rebroadcast system for IP-TV content was retrofitted with a combination of ... -
Biometric identities and e-government services.
(IGI Global, 2006)Governments are using the Internet and e-commerce technologies to provide public services to their citizens (Watson & Mundy, 2001). In so doing, governments aim to form better relationships with businesses and citizens by ... -
Biometric technology and smartphones: a consideration of the practicalities of a broad adoption of biometrics and the likely impacts
(IEEE, 2016-04)The Widespread Global Adoption of Smartphones across all demographics and the rapid commoditization of the technology to the point at which an entry-level device can be sold profitably for less than US$100 suggest that we ...