Browsing by Title

Now showing items 1525-1544 of 14641

    • Bioinformatic identification and analysis of extensins in the plant kingdom 

      Liu, Xiao; Wolfe, Richard; Welch, Lonnie R.; Domozych, David S.; Popper, Zoë A.; Showalter, Allan M. (Public Library of Science, 2016-02-26)
      Extensins (EXTs) are a family of plant cell wall hydroxyproline-rich glycoproteins (HRGPs) that are implicated to play important roles in plant growth, development, and defense. Structurally, EXTs are characterized by the ...

    • Bioinspired micropatterned adhesive surfaces for medical applications: a numerical investigation of fibrillar adhesives and swellable microneedle arrays 

      Tarpey, Ruth (NUI Galway, 2024-03-21)
      Traditional sutures and tissue adhesives can cause adverse effects, inflicting additional damage to the tissue, resulting in toxic chemical residues, and increasing the risk of infection. Bioinspired adhesives have ...

    • Biological activities of lipopolysaccharides are determined by the shape of their lipid a portion 

      Schromm, Andra B.; Brandenburg, Klaus; Loppnow, Harald; Moran, Anthony P.; Koch, Michel H. J.; Rietschel, Ernst TH.; Seydel, Ulrich (Wiley-Blackwell, 2000-04-01)
      Lipopolysaccharide (LPS) represents a major virulence factor of Gram-negative bacteria ('endotoxin') that can cause septic shock in mammals including man. The lipid anchor of LPS to the outer membrane, lipid A, has a ...

    • Biological and chemical analysis of azaspiracids and amphidinols originating from dinoflagellate strains associated to Irish waters 

      Murphy, Elliot Charles (NUI Galway, 2024-04-15)
      Microalgae have the potential to produce biologically active metabolites which can be toxic, affect our fisheries and endanger food safety. Due to their active nature these toxins can also have therapeutic benefits when ...

    • A biological and pharmacological investigation of the unfolded protein response in models of breast cancer 

      Leuzzi, Brian (NUI Galway, 2020-11-20)
      Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ...

    • Biological applications of knowledge graph embedding models 

      Mohamed, Sameh K.; Nounu, Aayah; Nováček, Vít (Oxford University Press (OUP), 2020-02-17)
      Complex biological systems are traditionally modelled as graphs of interconnected biological entities. These graphs, i.e. biological knowledge graphs, are then processed using graph exploratory approaches to perform different ...

    • Biological characterization of a human mesenchymal stromal cell product 

      Creane, Michael (2016-07-21)
      The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ...

    • Biological characterization ofcampylobacter fetuslipopolysaccharides 

      Moran, Anthony P.; O'Malley, David T.; Vuopio-Varkila, Jaana; Varkila, Kari; Pyhälä, Liisa; Saxén, Harri; Helander, Ilkka M. (Oxford University Press (OUP), 1996-08-01)
      Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed ...

    • Biological insights from 108 schizophrenia-associated genetic loci 

      Ripke, Stephan; Neale, Benjamin M.; Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. C.; Ann Chong, Siow; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Ausrele Kucinskiene, Zita; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Lee Chee Keong, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lönnqvist, Jouko; Macek Jr, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Van Os, Jim; Endophenotypes International Consortium, Psychosis; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon-Cheong; Spencer, ChrisC. A.; Stahl, Eli A.; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H. M.; Wormley, Brandon K.; Simon Xi, Hualin; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefansson, Kari; Visscher, Peter M.; Trust Case-Control Consortium, Wellcome; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H. R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; St Clair, David; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O’Donovan, Michael C. (Springer Nature, 2014-07-22)
      Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ...

    • Biological phosphorus removal during high-rate, low-temperature, anaerobic digestion of wastewater 

      Keating, Ciara; Chin, Jason P.; Hughes, Dermot; Manesiotis, Panagiotis; Cysneiros, Denise; Mahony, Therese; Smith, Cindy J.; McGrath, John W.; O'Flaherty, Vincent (Frontiers Media, 2016-03-03)
      We report, for the first time, extensive biologically mediated phosphate removal from wastewater during high-rate anaerobic digestion (AD). A hybrid sludge bed/fixed-film (packed pumice stone) reactor was employed for ...

    • Biological study of the angiogenesis inhibitor n-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin 

      Zhao, Yunxue; Zhou, Ying; O’ Boyle, Kathy M.; Murphy, Paul V. (Wiley-Blackwell, 2010-06-01)
      The alpha-glucosidase inhibitors N-methyl-1-deoxynojirimycin (MDNJ) and castanospermine have been shown to inhibit angiogenesis. A hybrid of 1-deoxynojirimycin (DNJ) and an aryl-1,2,3-triazole, which inhibits both an ...

    • The biology of the slug-killing Tetanocera elata (Diptera: Sciomyzidae) and its potential as a biological control agent for pestiferous slugs 

      Hynes, Tracy (15-02-05)
      Laboratory experiments were carried out to determine the effects of controlled temperatures (14oC, 17oC, 20oC, 23oC, and 26oC) and ambient outdoor and laboratory temperatures on the development and predation capacity of ...

    • Biomarkers: are realism and control mutually exclusive in integrated pollution assessment? 

      Wilson, J.G.; McHugh, B.; Giltrap, M. (Elsevier BV, 2014-12-01)

    • A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery 

      Daly, William; Yao, Li; Zeugolis, Dimitrios I.; Pandit, Abhay (The Royal Society, 2011-11)
      Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ...

    • Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons 

      Alexander, Jennifer C.; Browne, Shane; Pandit, Abhay; Rochev, Yury (Public Library of Science (PLoS), 2013-06-03)
      Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ...

    • Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair 

      Sadasivan, Saraswathi (2017-10-10)
      The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ...

    • Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives 

      O'Neill, Hugh S.; Gallagher, Laura B.; O'Sullivan, Janice; Whyte, William; Curley, Clive; Dolan, Eimear; Hameed, Aamir; O'Dwyer, Joanne; Payne, Christina; O'Reilly, Daniel; Ruiz-Hernandez, Eduardo; Roche, Ellen T.; O'Brien, Fergal J; Cryan, Sally Ann; Kelly, Helena; Murphy, Bruce; Duffy, Garry P. (Wiley-Blackwell, 2016-02-03)
      Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical ...

    • A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination 

      Mathew, Asha (2013-10-03)
      Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ...

    • Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease 

      Kotla, Niranjan (NUI Galway, 2021-01-25)
      Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ...

    • A biomaterials approach to peripheral nerve repair 

      Daly, William (2014-04-09)
      Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ...