Browsing by Title
Now showing items 1916-1935 of 14646
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Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ... -
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage
(Wiley, 2013-08-02)The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the intra-S-phase checkpoint. Its interactions with other replication ... -
Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy
(Public Library of Science, 2012-04-19)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ... -
Cell cycle-dependent mobility of Cdc45 in living cells determined by fluorescence correlation spectroscopy.
(Public Library of Science, 2012)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ... -
Cell fate commitment during nervous system establishment: from stem cells to neurons
(NUI Galway, 2020-07-06)Members of the early-branching metazoan phylum of Cnidaria are well-recognized as a sister group to bilaterians making them an ideal candidate to study the evolution of the eumetazoan nervous system. I began to unravel the ... -
Cell morphology and focal adhesion location alters internal cell stress
(The Royal Society, 2014-10-08)Extracellular mechanical cues have been shown to have a profound effect on osteogenic cell behaviour. However, it is not known precisely how these cues alter intracellular mechanics to initiate changes in cell behaviour. ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
(2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Cell viability in three ex vivo rat models of spinal cord injury
(Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Cell wall evolution and diversity
(Frontiers Media SA, 2012-01-01)Plant cell walls display a considerable degree of diversity in their compositions and molecular architectures. In some cases the functional significance of a particular cell wall type appears to be easy to discern: secondary ... -
Cell wall evolution and diversity
(Frontiers Media, 2012-07-06)Plant cell walls display a considerable degree of diversity in their compositions and molecular architectures. In some cases the functional significance of a particular cell wall type appears to be easy to discern: secondary ... -
Cell wall immunocytochemistry and histology of hemiparasitism in Rhinanthus minor L. and Odontites vernus (Bellardi) Dumort: interactions at haustorial interfaces and implications for grassland biodiversity
(2013-11-21)Parasitic plants develop specialised grafting organs called haustoria to attach to and infiltrate host plant organs to access nutrients. The outcome of the parasitic process is largely determined where cell walls of the ... -
The cell walls of pteridophytes and other green plants - a review
(British Pteridological Society, 2006-12-22)The cell wall is one of the defining characteristics of plants and is a fundamental component in normal growth and development. Cell wall composition is a potentially valuable source of phylogenetic information as notable ... -
A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
(NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellmix: a comprehensive toolbox for gene expression deconvolution
(Oxford University Press (OUP), 2013-07-03)Gene expression data are typically generated from heterogeneous biological samples that are composed of multiple cell or tissue types, in varying proportions, each contributing to global gene expression. This heterogeneity ... -
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
(Springer Verlag, 2013-06-18)Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ... -
Cellular interactions in the tumour microenvironment during inflammation-associated carcinogenesis
(2017-11-30)The colon tumour microenvironment is highly stromal in composition and a greater stromal cell density correlates with a poor prognosis for patients. The majority of these stromal cells are of mesenchymal origin (MSCs) and ... -
Cellular plasticity in prostate cancer bone metastasis
(Hindawi Limited, 2015-01-01)Purpose. Experimental data suggest that tumour cells can reversibly transition between epithelial and mesenchymal states (EMT and MET), a phenomenon known as cellular plasticity. The aim of this review was to appraise the ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
(2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Cellular responses to endoplasmic reticulum stress: Role of autophagy and cell death
(2014-12-03)This PhD thesis describes cellular responses to the induction of endoplasmic reticulum (ER) stress, focusing on the role of autophagy and cell death. Pro-survival role of unfolded protein response (UPR) is analysed by ...