Browsing College of Medicine, Nursing and Health Sciences by Title
Now showing items 96-115 of 855
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Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
(Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
'Choose Safety'. An evaluation of a Health and Safety module for use in secondary schools. Health Promotion Research Centre, NUI, Galway
(Health Promotion Research Centre, NUI Galway, 2009-01)The overall aim of this project was to comprehensively evaluate the pilot of the 'Choose Safety' module developed by the H.S.A. The module is a teaching and learning pack for post-primary students. The main objectives of ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
(Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
(SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat
(2007)The olfactory bulbectomized (OB) rat is a well characterized animal model that exhibits a number of behavioural and neurochemical changes that have relevance to clinical depression. Hyperactivity in the open field is the ... -
Circuitry underlying regulation of the serotonergic system by swim stress
(Society for Neuroscience, 2003-02-01)The dorsal raphe nucleus (DR)–serotonin (5-HT) system has been implicated in depression and is dramatically affected by swim stress, an animal model with predictive value for antidepressants. Accumulating evidence implicates ... -
Circulating MicroRNAs in cancer
(Humana Press, 2016-11-09)It is believed that microRNAs have potential as circulating biomarkers of disease, however successful clinical implementation remains a challenge. This chapter highlights broad variations in approaches to microRNA analysis ... -
Clinical applications of gene expression in colorectal cancer.
(2013)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
The clinical characteristics and correlates of lithium toxicity in a tertiary referral centre
(Springer Verlag, 2019-01-10)Introduction Lithium is a medication indicated for the treatment of bipolar disorder and treatment-resistant depression, with a narrow therapeutic index. Overdose, either acute or chronic can result in neurological symptoms, ... -
Clinical research nurses’ expectations and realities of their role: A qualitative evidence synthesis
(Wiley, 2019-12-17)Aims To synthesise the available body of qualitative studies relating to clinical research nurses’ experiences of their role. Methods A systematic search of the literature in five databases was undertaken: CINAHL, ... -
Cluster randomisation and design effects in school surveys: an exploration of the Irish Health Behaviours in School-aged Children data.
(National Institute of Health Sciences, 2008-09)School surveys are typically conducted in classrooms where children are clustered and thus each participating student is not fully independent of others. Such unavoidable cluster randomisation increases the size of standard ... -
A cluster randomised controlled trial evaluating the effectiveness of a structured pulmonary rehabilitation education programme for improving the health status of people with chronic obstructive pulmonary disease (COPD): The PRINCE Study protocol.
(BioMed Central, 2011-01-18)A key strategy in improving care for people with chronic obstructive pulmonary disease (COPD) is the provision of pulmonary rehabilitation programmes. Pulmonary rehabilitation programmes have been successful in improving ... -
Cognition and pain
(Lippincott, Williams & Wilkins, 2014-06)Purpose of reviewPain and cognition share common neural substrates and are known to interact reciprocally. This has implications for treatment and management of pain conditions; pain can negatively affect cognitive ... -
Cognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery.
(2015-09-26)While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of ... -
Cognitive impairment in patients with chronic neuropathic or radicular pain: An interaction of pain and age
(Frontiers Media, 2017-06-13)A growing body of empirical research has confirmed an association between chronic pain and cognitive dysfunction. The aim of the present study was to determine whether cognitive function is affected in patients with a ... -
A cognitive occupation-based programme for people with MS: acceptability, feasibility, and experiences of people with multiple sclerosis
(Taylor and Francis Group, 2023-07-26)Purpose COB-MS is an eight-session, Cognitive Occupation-Based programme for people with both MS and cognitive difficulty – designed to enhance cognition and daily functioning, through a combination of goal-setting, ... -
A cognitive occupation-based programme for people with multiple sclerosis: A new occupational therapy cognitive rehabilitation intervention
(SAGE Publications, 2019-05-08)Introduction: Cognitive difficulties have been reported to have the greatest effect on function and quality of life in people with multiple sclerosis, affecting 50 60% of people. To date, few interventions have been ... -
A cognitive occupation-based programme for people with multiple sclerosis: a study to test feasibility and clinical outcomes
(Hindawi Publishing Corporation, 2018-05-02)Cognitive impairments are common in MS and affect personal, social, and occupational functioning. There is a developing body of evidence highlighting the role of cognitive rehabilitation, but there is still no evidence for ... -
"Come for the weight-loss, stay for the enjoyment" - exploring attributions for initiating and maintaining exercise.
(Psychological Society of Ireland, 2001-05)The potential benefits from engaging in physical activity and exercise in terms of both physical and mental health are well established. Regular exercise has been demonstrated to have preventative effects for several chronic ...